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L-Proline was utilized as an efficient organo-catalyst for the environmentally benign synthesis of 3-substituted coumarins by the Knoevenagel condensation of substituted 2-hydroxybenzaldehydes with reactive methylene compounds under solvent free conditions.

An efficient synthesis of 2-substituted oxazolines from aldehydes and 2-amino alcohol using (diacetoxyiodo)benzene as an oxidant, is reported. (Diacetoxyiodo)benzene acts as a mild dehydrogenating agent to convert the initially formed oxazolidine from aldehyde and 2-amino alcohol to furnish 2-substituted oxazoline. Similarly, 3-aminopropanol and aldehydes gives the corresponding 2-substituted oxazines.

A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3-methyl-1-phenyl-2-pyrazolin-5-one, an aromatic aldehyde, and malononitrile catalysed by sulfamic acid in ethanol.

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Oxazole derivatives R 0220Efficient Oxidative Conversion of Aldehydes to 2-Substituted Oxazolines and Oxazines Using (Diacetoxyiodo)benzene. -The heterocycles are synthesized by reaction of amino alcohols with alipatic and aromatic aldehydes. The method is also applicable to chiral substrates. -(KARADE*, N. N.; TIWARI, G. B.; GAMPAWAR, S.

magnified image 4‐Alkyl or aryl‐1,4‐dihydropyrimidines were readily oxidized by (diacetoxyiodo)benzene under mild reaction conditions to the corresponding pyrimidine derivatives in good to excellent yields. J. Heterocyclic Chem., (2010).

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