Abstract:In this present study, the leaf extracts of Litsea liyuyingi, were subjected to evaluate the phytochemical screenings, thrombolytic, membrane stabilizing, antioxidant, antimicrobial, cytotoxic, antinociceptive, anti-diarrheal
Present study aspires at the design of an immediate release formulation with prospective use of fexofenadine hydrochloride by exploring the effect of sodium starch glycolate as super disintegrant. Fexofenadine hydrochloride immediate release tablets (Formulations F-1, F-2, F-3, F-4 and F-5) using different ratios of sodium starch glycolate as a disintegrant were prepared by direct compression method. Standard physicochemical tests were performed for all the formulations. Dissolution studies of the formulations were done in phosphate buffer, pH 6.8 using USP apparatus II (paddle apparatus) at 50 rpm. Percent release of fexofenadine hydrochloride of formulations F-1, F-2, F-3, F-4 and F-5 were 89.98%, 90.98%, 92.95, 96.92% and 99.85%, respectively after 1 h and the release pattern followed the zero order kinetics. The release rate in the formulation F-5 was higher compared to other formulations and the studied market products. Sodium starch glycolate speed up the release of the drug from the core tablets, and the release of fexofenadine hydrochloride from tablets was directly proportional to the amount of sodium starch glycolate present in the formulations and there by produced immediate action.
ABSTRACT:The ethanolic extract of leaves of Sesbania grandiflora and their organic and aqueous soluble partitioning substances were evaluated for thrombolytic and membrane stabilizing potentials in vitro. In thrombolytic assay, among all partitionates, the ethyl acetate soluble fraction showed highest percent of clot lysis (59.57%) as compared to 69.23% and 3.07% exhibited by the standard streptokinase and water (negative control), respectively. With respect to the membrane stabilizing activity, ethyl acetate soluble fractions of S. grandiflora also profoundly inhibited the hemolysis of erythrocytes induced by osmosis (64.30 ± 0.64%) and heat (57.21 ± 0.69%), respectively. In contrast, standard acetyl salicylic acid resulted in 70.12 ± 26% inhibition of osmotically-induced hemolysis and slightly higher level of protection against heat-induced hemolysis (73.90 ± 0.29%). The ethanol extract of leaves of S. grandiflora revealed significant percentage of thrombolytic and membrane stabilizing activities.
The ethanolic plant extracts of Asparagus racemosus and their partitionates were assessed for thrombolytic, membrane stabilizing, antimicrobial and antioxidant activity in vitro. Methods: The collected plant was dried and grinded. The coarse powder was shocked in 2000 mL of 90% methanol for several days then filtrated. At 40°C the volume of crude ethanolic extract (CEE) was reduced by a vacuum rotary evaporator followed by concentrated aqueous ethanol extractive was fractionated into petroleum ether (PSF), carbon tetrachloride (CTSF), chloroform soluble fraction (CSF) and aqueous (AQSF) soluble fractions. Results: In thrombolytic assay among all the extractives, carbon tetrachloride soluble fraction (CTSF) showed the highest clot lysis (41.48 ± 0.43%) activity as compared with standard streptokinase (65.16 ± 0.16%). With respect to the membrane stabilizing activity, chloroform soluble fraction (CSF) profoundly inhibited the lysis of erythrocytes (80.86 ± 0.36%) induced by osmosis, whereas reference standard acetyl salicylic acid (ASA) resulted in (88.99 ± 0.39%) inhibition of lysis. On the other hand, CTSF showed slightly higher level of protection against heat-induced hemolysis (85.68 ± 0.75%) as same as with ASA, (85.68 ± 0.75%)). In antimicrobial investigation, crude ethanol extract (CEE) and their partitioning fractions exhibited moderate inhibition of growth of some examined bacteria. The total phenolic content was found maximum (930.94 mg of GAE/gm) in CEE of A. racemosus. The antioxidant potentials in term of DPPH free radical scavenging assay showed EC50 values 2.62 μg/mL by aqueous soluble fraction (AQSF) in comparison to ascorbic acid 2.48 μg/mL as a reference standard. Conclusions: This study was conducted to validate the A. racemosus plant as thrombolytic, membrane stabilizing agent, antimicrobial and antioxidant.
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