Bioactivities and Chemical Profiling of Sesbania grandiflora (L.) Poir. Leaves Growing in Bangladesh

Laboni, Farhina Rahman; Karim, Samira; Uddin, Jalal; Labu, Zubair Khalid

doi:10.3329/dujps.v15i2.30932

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…The resulting solution was used as such for in vitro evaluation of clot lysis activity. The thrombolytic activities of the various fractions were evaluated by reported method (Laboni et al, 2016, Daginawala et al, 2006.…”

Section: In Vitro Thrombolytic Activitymentioning

confidence: 99%

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Ferdosh

Laboni

Rashid

et al. 2018

Natural Product Research

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The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (P>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).

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Section: In Vitro Thrombolytic Activitymentioning

confidence: 99%

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Ferdosh

Laboni

Rashid

et al. 2018

Natural Product Research

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“…S. grandiflora is a soft wooded flowering tree that grows in Asian countries including Bangladesh, India, Malaysia and Indonesia [128,129]. In the in vitro RBC membrane stabilization assay, this plant protected the cell membrane from lysis [129][130][131]. In different in vivo study models like carrageenan induced paw edema, cotton pellet induced granuloma and adjuvantinduced arthritis model, the flower [132], bark [128,133] and root extract [134] of S. grandiflora successfully attenuated inflammation.…”

Section: Anthocephalus Cadamba (Roxb) Miqmentioning

confidence: 99%

Management of inflammatory disorders: A brief review of selected ethnomedicinal plants

Akhtar,

Khan,

Zahan

2023

JPP

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Medicinal plants have immense significance to treat various diseases and have great potential to discover and develop new therapies. This paper aims to summarize the in vitro and in vivo investigations conducted to evaluate the anti-inflammatory activities of selected medicinal plants of Bangladesh. The anti-inflammatory active molecules reported from those selected plants have also been highlighted. The species included in this review are Abelmoschus esculentus (L.) Moench, Asparagus racemosus Willd., Blumea lacera (Burm.f.) DC., Butea monosperma (Lam.) Taub., Cheilocostus speciosus (J.Koenig) C.D.Specht., Mussaenda roxburghii Hook. f., Anthocephalus cadamba (Roxb.) Miq., Phyllanthus reticulatus Poir., Sesbania grandiflora (L.) Pers. and Spondias pinnata (L. f.) Kurz. The toxic effect of these plants has also been included briefly. We hope that this overview will shed some light on the function of these plants and their molecules in the treatment of various inflammatory diseases and will attract the attention of investigators interested in designing novel therapeutic approaches.

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“…The thrombolytic activity of the prepared extracts was evaluated by the method of Daginawala, where streptokinase (SK) was used as a standard drug [7,8]. Venous blood (5 ml) was drawn from healthy volunteers, and transferred in different pre-weighed sterile tubes (1 ml/tube) to form clots.…”

Section: In Vitro Thrombolytic Activitymentioning

confidence: 99%

Justification of Traditional Uses of (Shatavari) - A Miracle Herb

Karim¹,

Islam²,

Tasnim³

et al. 2017

Open Bioact. Compd. J.

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The ethanolic plant extracts of Asparagus racemosus and their partitionates were assessed for thrombolytic, membrane stabilizing, antimicrobial and antioxidant activity in vitro. Methods: The collected plant was dried and grinded. The coarse powder was shocked in 2000 mL of 90% methanol for several days then filtrated. At 40°C the volume of crude ethanolic extract (CEE) was reduced by a vacuum rotary evaporator followed by concentrated aqueous ethanol extractive was fractionated into petroleum ether (PSF), carbon tetrachloride (CTSF), chloroform soluble fraction (CSF) and aqueous (AQSF) soluble fractions. Results: In thrombolytic assay among all the extractives, carbon tetrachloride soluble fraction (CTSF) showed the highest clot lysis (41.48 ± 0.43%) activity as compared with standard streptokinase (65.16 ± 0.16%). With respect to the membrane stabilizing activity, chloroform soluble fraction (CSF) profoundly inhibited the lysis of erythrocytes (80.86 ± 0.36%) induced by osmosis, whereas reference standard acetyl salicylic acid (ASA) resulted in (88.99 ± 0.39%) inhibition of lysis. On the other hand, CTSF showed slightly higher level of protection against heat-induced hemolysis (85.68 ± 0.75%) as same as with ASA, (85.68 ± 0.75%)). In antimicrobial investigation, crude ethanol extract (CEE) and their partitioning fractions exhibited moderate inhibition of growth of some examined bacteria. The total phenolic content was found maximum (930.94 mg of GAE/gm) in CEE of A. racemosus. The antioxidant potentials in term of DPPH free radical scavenging assay showed EC50 values 2.62 μg/mL by aqueous soluble fraction (AQSF) in comparison to ascorbic acid 2.48 μg/mL as a reference standard. Conclusions: This study was conducted to validate the A. racemosus plant as thrombolytic, membrane stabilizing agent, antimicrobial and antioxidant.

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Bioactivities and Chemical Profiling of Sesbania grandiflora (L.) Poir. Leaves Growing in Bangladesh

Cited by 5 publications

References 3 publications

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Management of inflammatory disorders: A brief review of selected ethnomedicinal plants

Justification of Traditional Uses of (Shatavari) - A Miracle Herb

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