A variety of voltammetric methods have been carried out for determination of brexpiprazole (BRX) using cyclic voltammetry (CV) and two different type anodic stripping methods; differential pulse (AS-DP) and square wave (AS-SWV) at modified carbon paste electrode with gold nanoparticles (AuNPs-CPEs). Additionally, electrochemical impedance spectroscopy (EIS) technique has been utilized for characterization of the different electrodes. Electrochemical oxidation behavior of BRX shows an irreversible anodic peak at 0.88 V versus Ag/AgCl, in Britton-Robinson buffer (BR) at pH 4.0, 50s preconcentration time and −0.5 deposition potential. Rectilinear relationship between the peak current versus concentration was obtained over the ranges of 1.32 × 10 −6 -6.45 × 10 −6 and 1.32 × 10 −7 -6.45 × 10 −7 mol L −1 for AS-DP and AS-SWV respectively. The lowest concentration that can be detected for both for AS-DP and AS-SWV was 3.99 × 10 −7 and 3.32 × 10 −8 mol L −1 respectively; the utilized methods have been devoted adequately for the estimation of BRX in its pure and dosage form.

A sensitive voltammetric technique for the determination of avanafil (AVA) has been investigated at a carbon paste electrode modified with Zinc oxide nanoparticles and multi-walled carbon nanotubes (ZnO-NPs/MWCNT/CP). The study investigated the electrochemical behavior of AVA, and the morphology of the modified electrode was evaluated by transmission electron microscopy, scanning electron microscopy, and X-ray diffraction patterns. The influence of different electrodes and the content of ZnO-NPs on the voltammetric behavior of AVA were evaluated. Square wave voltammetry was studied and a linear correlation resulted within the range of (1.3-16 μg ml −1 ) with correlation coefficient 0.999, LOD 0.342 μg ml −1 and LOQ 1.141 μg ml −1 . The proposed procedure was applied successfully for the determination of AVA with good recovery in commercial dosage form and human plasma. The technique was validated and found to be accurate and reproducible according to the ICH guidelines.

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Two chromatographic techniques were developed and validated for simultaneous determination of the newly co-formulated antidiabetic combination linagliptin and empagliflozin in their pure form and film-coated tables. The first technique was UPLC; the separation and resolution of both analytes were achieved using a Zorbax eclipse plus C 18 column applying an isocratic elution based on phosphate buffer pH 4-acetonitrile (65:35, v/v) as a running mobile phase at flow rate 1.5 ml/min and the effluent was monitored at 220 nm. Augmentation of Lean Six Sigma with UPLC and

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Diabetics are liable to fatal atherosclerotic cardiovascular diseases. It is clinically attributed to their imbalanced plasma lipoproteins. Fixed‐dose combination “polypill” of simvastatin (10 mg) and sitagliptin phosphate (100 mg) is mainly indicated for the treatment of diabetic dyslipidemia. Novel green micellar electrokinetic capillary chromatographic method has been developed for simultaneous determination of simvastatin and sitagliptin phosphate in binary synthetic mixtures and their pharmaceutical formulation. Separation was achieved using a deactivated fused silica capillary (50 cm effective length × 50 μm id) through a background running electrolyte of 100 mM borate buffer (pH 9.1) and 100 mM sodium dodecyl sulfate. Diode array detection was set at 238 and 210 nm for simvastatin and sitagliptin phosphate, respectively. All experimental parameters were closely varied and optimized. Both drugs declared good linearities over the range of 10–100 μg/mL. Proposed study was validated according to International Council for Harmonization guidelines. It was applied to the assay of laboratory‐made binary mixtures and marketed tablets. Electrophoretic assay was compared with a reported spectrophotometric one. Satisfactory t‐test and F‐ratio indicated insignificant differences between both methods. Moreover, it is the first capillary electrophoretic simultaneous assay for simvastatin and sitagliptin phosphate, and fits a linear correlation with the green analytical attributes.