The rate of 0, utilization by both pigmented and non-pigmented strains of Pseudosmonas aeruginosa was greater with 2 yo (~1 1 7) Casitone as substrate than with 0.1 M-glucose as substrate. P. aeruginosa readily catabolized Casitone, amino acids and other nitrogenous compounds with the production of an alkaline reaction even in the presence of 0.5 0 4 (wlv) glucose. Other species of Pseudomonas studied varied in their utilization of these compounds, suggesting a different and possibly satisfactory approach to the identification and classification of species within the genus Pseudornonas.
D-Glucaric acid excretion was followed in psychotic patients treated with phenothiazines for 12 days and in a control group of subjects who had no psychiatric disease. About half the psychiatric patients had a treatment-related rise in D-glucaric acid excretion compatible with enzyme induction. These patients had fewer and less severe neurologic side effects than those who did not have a significant rise in urinary D-glucaric acid levels. It is concluded that individual differences in metabolism of phenothiazines may in part account for the variability in clinical response to these drugs.
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