Persea americana Mill. seed or avocado seed contains phytochemical components such as flavonoids, tannins, saponins, phenolic, and alkaloid. The phenolic compounds of avocado seed are mainly catechin, hydroxybenzoic acid, caffeic acid, chlorogenic acid, coumaric acid, ferulic acid, and triterpenoid glycosides. This review also discusses various extraction methods using an organic solvent, inorganic solvent, and a mixture of solvents. The analysis methods to measure the chemical properties of extracted phytochemicals from avocado seed are discussed. The functional properties of the phytochemicals obtained from the seed are presented.

Averrhoa bilimbi grows in tropical and subtropical countries and has the potential to be used as phytopharmaceuticals. Averrhoa bilimbi leaves and fruits contain phytochemicals, such as alkaloids, saponins, tannins, flavonoids, phenols, and triterpenoids. These compounds are mostly obtained by extraction and can be used for their pharmacological properties in the form of antibacterial, antivirus, total cholesterol level reducer, and antioxidant. Further research and development need to be carried out on the effectiveness and performance of Averrhoa bilimbi.

Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay). Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg. Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production.

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