Inhibitions of acute and chronic inflammations by Bixa orellana leaves extract

Zuraini, A.; Somchit, M. N.; Hamid, Roslida Abdul; Sukardi, S.; Fazira, A. J. Siti Erli; Yong, Yan; Lee, H. K.; Cheng, Xiaofang

doi:10.1055/s-2007-986858

Cited by 5 publications

(3 citation statements)

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“…An aqueous extract of Bixa leaves was shown to be an excellent anti-inflammatory agent against both acute and chronic inflammation in rats (Zuraini et al, 2007). Acute inflammatory reactions induced in rat paws by carageenan, histamine, serotonin and bradykinin were all inhibited by the oral administration of 50 mg/kg and 150 mg/kg of Bixa leaf extract.…”

Section: Anti-inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 98%

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Stohs

2013

Phytotherapy Research

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Bixa orellana leaf preparations have been used for many years by indigenous people for a variety of medicinal applications. Published research studies in animals indicate that various extracts of Bixa leaves exhibit antioxidant, broad antimicrobial (antibacterial and antifungal), anti-inflammatory, analgesic, hypoglycemic, and antidiarrheal activities. No studies have specifically assessed the ability of leaf extracts to inhibit urogenital infections although Bixa products have been used in folkloric medicine to treat gonorrhea and other infections. Few human studies have been conducted and published using Bixa leaf preparations. Many more studies have been conducted and published involving Bixa seed (annatto) extracts than with leaf extracts. No subchronic safety (toxicity) studies have been conducted in animals. A 6 month study in humans given 750 mg of leaf powder per day demonstrated no significant or serious adverse effects. Bixa leaf extracts appear to be safe when given under current conditions of use. However, additional human and animal controlled safety and efficacy studies are needed. In addition, detailed chemical analyses are required to establish structure-function relationships.

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Section: Anti-inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 98%

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Stohs

2013

Phytotherapy Research

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“…In a similar trial, the ethyl acetate extract (50 mg/kg) also reduced paw edema by 40%, being comparable to the efficiency of diclofenac (Moraes-Neto et al, 2022). Another work investigated the possible inflammatory mediators inhibited by the aqueous extract of the leaves, and the acute inflammation model was induced in Sprague-Dawley rats through the administration of carrageenan, histamine, serotonin and bradykinin in the hind legs, in addition to verifying to regression of granulomas in the model of chronic inflammation, so that in all models, the extract led to the reduction of inflammation, using doses between 50 and 150 mg/kg (Zuraini et al, 2007).…”

Section: Pharmacology Approaches Of Bixa Orellana Leavesmentioning

confidence: 99%

“…These last two activities are important for the treatment of inflammations in the urinary and prostatic tracts, since the various compounds present in the leaves have shown different ways of inhibiting the inflammatory process and antioxidant mechanisms, which in turn are important in the first stages of inflammation (Guevara-Cholón & Rosales-Azabache, 2021; M.A. Tagne et al, 2019;Zarza-García et al, 2017;Zuraini et al, 2007). Added to this, the antibacterial activity against E. coli is also an important contribution for the treatment of urinary disorders, since this bacterium is the main cause of urinary infections in humans (Kar et al, 2022;Shilpi et al, 2006).…”

Section: Pharmacology Approaches Of Bixa Orellana Leavesmentioning

confidence: 99%

A review of Bixa orellana L. (Annatto) leaves as medicinal resource: Use in the population as complementary medicine, phytotherapeutic action and quality parameters

Molina-Romani¹,

Rivera²,

Albuquerque³

2023

NRFHH

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Bixa orellana, known as Annato or Achiote, is a species popularly used in various countries of America as a dye and medicine. Its leaves possess several biological activities and are commonly marketed as filters. However, despite some ethnomedicinal and pharmacological studies with Bixa orellana leaves having been published, there is a lack of review articles that collect this information. In addition, the few studies about the quality parameters of these filters must be addressed jointly so that the usefulness of existing information can be better addressed in the discussion of commercial regulation. In this way, this review aims to compile systematically useful information about the medicinal use and pharmacology of B. orellana leaves, in addition to channeling the studies on the quality parameters of filters, which in turn can define the quality, efficacy and safety of the marketed products. As a result of the review, the searches showed that the leaves of B. orellana are traditionally used for various purposes, including treatment of headache, bronchitis, and inflammation, in addition to using as a diuretic, analgesic, antiophidic, among others. These findings were corroborated by pharmacological studies, which also point to other biological activities such as antioxidant, antimicrobial, anti-inflammatory, neurodepressant and gastrointestinal modulator through the administration of leaf extracts. Finally, stability and extraction yield studies were also important in providing data for implementing quality control of B. orellana products.

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Phytochemistry, biological activities and potential of annatto in natural colorant production for industrial applications – A review

Islam

Rather

Mohammad

2016

Journal of Advanced Research

126

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Bixa orellana commonly known as annatto is one of the oldest known natural dye yielding plants native to Central and South America. Various parts of annatto have been widely used in the traditional medical system for prevention and treatment of a wide number of health disorders. The plethora of traditional uses has encouraged researchers to identify and isolate phytochemicals from all parts of this plant. Carotenoids, apocarotenoids, terpenes, terpenoids, sterols, and aliphatic compounds are main compounds found in all parts of this plant and are reported to exhibit a wide range of pharmacological activities. In recent years annatto has received tremendous scientific interest mainly due to the isolation of yellow-orange natural dye from its seeds which exhibits high biodegradability, low toxicity, and compatibility with the environment. Considerable research work has already been done and is currently underway for its applications in food, textile, leather, cosmetic, solar cells, and other industries. The present review provides up-to-date systematic and organized information on the traditional usage, phytochemistry and pharmacology of annatto. It also highlights its non-food industrial applications in order to bring more interest on this dye plant, identifies the existing gaps and provides potential for future studies. Studies reported in this review have demonstrated that annatto holds a great potential for being exploited as source of drugs and a potential natural dye. However, further efforts are required to identify extract biomolecules and their action mechanisms in exhibiting certain biological activities in order to understand the full phytochemical profile and the complex pharmacological effects of this plant.

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Inhibitions of acute and chronic inflammations by Bixa orellana leaves extract

Cited by 5 publications

References 0 publications

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

A review of <i>Bixa orellana</i> L. (Annatto) leaves as medicinal resource: Use in the population as complementary medicine, phytotherapeutic action and quality parameters

Phytochemistry, biological activities and potential of annatto in natural colorant production for industrial applications – A review

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