The phytochemical potential of Averrhoa bilimbi – A review

Setyawan, Hendrix Yulis; Sukardi, S.; Nareswari, B F

doi:10.1088/1755-1315/733/1/012091

Cited by 12 publications

(20 citation statements)

References 8 publications

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“…The phytochemical screening analysis indicated that the leaves of A.bilimbi contained flavonoids, alkaloids, and saponins (Setyawan et al, 2021). Table 1 presents the data of the phytochemical screening test.…”

Section: Results Of Phytochemical Screeningmentioning

confidence: 99%

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Abdillah

Fauziah²,

Lestari³

et al. 2022

Pharmaciana

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Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15 th day, the normal group was given vehicle (Na CMC 5%), negative control group was given highfat feed, a positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animals were treated until the 28 th day. On day 29, the blood were taken to determine the total cholesterol andtriglyceride levels using clinical photometer 5010 v5+. The data were statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).

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Section: Results Of Phytochemical Screeningmentioning

confidence: 99%

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Abdillah

Fauziah²,

Lestari³

et al. 2022

Pharmaciana

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“…Penggunaan bahan bioaktif dari tumbuhan yang potensial digunakan pada pengawetan telur konsumsi adalah daun belimbing wuluh (Averrhoa bilimbi L). Bagian-bagain yang dapat dimanfaatkan dari belimbing wuluh adalah daun, buah, dan akar [5]. Hasil uji fitokimia ekstrak kasar metanol daun belimbing wuluh menunjukkan bahwa daun ini mengandung senyawa-senyawa metabolit sekunder seperti alkaloida, flavonoida, tanin, dan saponin [5,6].…”

Section: Pendahuluanunclassified

“…Bagian-bagain yang dapat dimanfaatkan dari belimbing wuluh adalah daun, buah, dan akar [5]. Hasil uji fitokimia ekstrak kasar metanol daun belimbing wuluh menunjukkan bahwa daun ini mengandung senyawa-senyawa metabolit sekunder seperti alkaloida, flavonoida, tanin, dan saponin [5,6]. Adanya kandungan senyawa metabolit sekunder tersebut maka daun belimbing wuluh memiliki sifat antioksidan [3,4].…”

Section: Pendahuluanunclassified

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Oksidasi, Daya Buih, dan Sifat Organoleptik Telur Ayam Ras yang Direndam dalam Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.)

Amelia

Suharyanto

Desia

et al. 2023

J. Livest. Animal Health

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Penelitian ini bertujuan untuk mengetahui pengaruh perendaman telur ayam ras dalam ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) (DBW) terhadap tingkat oksidasi, daya buih, dan karakteristik organoleptik telur ayam ras. Telur yang digunakan adalah telur ayam ras yang berumur maksimal 24 jam sejak ditelurkan. Esktraksi dilakukan dengan cara merebus DBW dalam air dengan suhu 85 ºC selama 10 menit, air rebusan kemudian disaring dan digunakan untuk penelitian. Perlakuan yang diaplikasi adalah P0 = tanpa perendaman (kontrol), P1 = perendaman dalam akuades, P2 = perendaman dalam ekstrak DBW 15%, P3 = perendaman dalam DBW 30%, dan P4 = perendaman dalam ekstrak DBW 45%. Tiap perlakuan diulang 3 kali dengan Rancangan Acak Lengkap (RAL). Data dianalisis dengan ANOVA dan uji lanjut DMRT (Duncan’s Multiple Range Test) dengan α = 0,05. Hasil penelitian menunjukkan bahwa perendaman telur dalam larutan ekstrak DBW konsentrasi 15% sudah dapat menekan oksidasi, daya buih yang tidak berubah dan kestabilan buih yang lebih tinggi; skor kecerahan warna yolk, skor bau telur, dan skor tingkat kesukaan yang lebih tinggi tanpa merubah sifat tekstur dan rasa. Kesimpulannya adalah bahwa telur ayam ras memiliki karakteristik fungsional dan organoleptik terbaik pada perendaman dalam ekstrak daun belimbing wuluh dengan konsentrasi 15% serta mampu menekan tingkat oksidasi.

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“…In general, belimbing wuluh commonly called with starfruit can be used to treat asthma, diabetes, cough, sore throat, canker sores, and fever [5][6][7]. Parts of the belimbing wuluh used for treatment include flowers, leaves, fruit, and stems.…”

Section: Introductionmentioning

confidence: 99%

Identification of Active Compounds from Averrhoa bilimbi L. (Belimbing Wuluh) Flower using LC-MS and Antidiabetic Activity Test using in vitro and in silico Approaches

Widiastuti

Sinaga²,

Warnasih

et al. 2023

Trends Sci

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Averrhoa bilimbi L., (Belimbing wuluh), is traditionally used for various antidiabetic, anti-larvicidal, antioxidant, hypoallergenic, antibacterial, antifungal, and anti-inflammatory treatments. This study evaluated 3 extracts (n-hexane, ethyl acetate, and n-butanol) isolated from starfruit flowers for antidiabetic effects using in vitro and in silico methods. Ethyl acetate extract showed the highest activity, followed by n-hexane and n-butanol extracts in inhibiting α-glucosidase. Each extract has an IC50 value of 89.84, 52.88, and 114.86 µg/mL. The active compounds contained in the ethyl acetate extract were determined using LC-MS, and the compounds with the highest retention time were identified as tautomycetin (8.585) and lithocholic acid (8.993). Tautomycetin and lithocholic acid showed promising results in the in silico test. The computational predictions showed that tautomycetin (−6.2 kcal/mol) and lithocholic acid (−10.0 kcal/mol) have better binding affinity values than miglitol (−5.4 kcal/mol). This is the first time the antidiabetic test of starfruit flower extract has been carried out. HIGHLIGHTS Averrhoa bilimbi L well-known as belimbing wuluh. is a highly nutritious plant and an endemic and tropical species mainly used as a traditional medicine to treat several diseases. Its fruit is food with economic value in Indonesia Extracts of ethyl acetate from the flower showed the highest antidiabetic activity with IC50 52.88 μg/mL In the phytochemical determination from Averrhoa bilimbi L flower using Liquid Chromatography Mass Spectrometer (LC-MS), several compounds were suspected of having antidiabetic activity, namely the compound lithocholic acid, and tautomycetin Lithocholic acid and tautomycetin have been tested for their bioactivity as antidiabetic with in vitro and in vivo methods GRAPHICAL ABSTRACT

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The phytochemical potential of Averrhoa bilimbi – A review

Cited by 12 publications

References 8 publications

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Oksidasi, Daya Buih, dan Sifat Organoleptik Telur Ayam Ras yang Direndam dalam Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.)

Identification of Active Compounds from Averrhoa bilimbi L. (Belimbing Wuluh) Flower using LC-MS and Antidiabetic Activity Test using in vitro and in silico Approaches

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