Taxus wallichiana, collected from the Himalayan region of Nepal, yielded, among others, three different endophytic fungi including Sporormia minima, Trichothecium sp., and an unidentified dimorphic fungus. Each was shown to produce paclitaxel in a culture medium. Each of these fungi represents a new report as a paclitaxel producer. The production of paclitaxel was confirmed by an immunoassay that utilized monoclonal antibodies, TLC chromatography as well as high performance liquid chromatography combined with on-line mass spectrometry.
Complexes of tailor-made ligands with life essential metal ions may be an emerging area to answer the problem of multi-drug resistance (MDR). The coordination complexes of VO(II), Co(II), Ni(II) and Cu(II) with the Schiff bases derived from 2-hydroxyacetophenone/2-chlorobenzaldehyde with 2-amino- 4-chlorophenol were synthesized and characterized by elemental analysis, molar conductance, electronic spectra, FT-IR, ESR, FAB mass, thermal and magnetic susceptibility measurements. The FAB mass and thermal data show degradation of the complexes. The ligand A (2-hydroxyacetophenone-2amino- -4-chlorophenol) behaved as tridentate and ligand B (2-chlorobenzylidene-2- -amino-4-chlorophenol) as bidentate, coordinating through O and N donors. The complexes [VO(A)(H2O)]?xH2O, [M(A)(H2O)n]?xH2O for Co and Ni, [Cu(A)(H2O)] and [VO(B)2]?xH2O, [M(B)2(H2O)n] for Co and Cu and [Ni(B)2] exhibited coordination numbers 4, 5 or 6. X-ray powder diffraction data (a = = 11.00417 ?, b = 11.706081 ? and c = 54.46780 ?) showed that [Cu(CACP)2(H2O)2], complex 8, crystallized in the orthorhombic system. The in vitro biological screening effects of the investigated compounds were tested against the bacteria Escherichia coli, Staphylococcus aureus and Streptococcus fecalis and the fungi Aspergillus niger, Trichoderma polysporum and Candida albicans by the serial dilution method. A comparative study of the MIC values of the Schiff base and their [M(B)2(H2O)2] complexes (Co(II), complex 6 and Cu(II), complex 8), indicated that the metal complexes exhibited a higher or lower antimicrobial activity than 2-chlorobenzylidene-2-amino-4-chlorophenol as the free ligand (B).
A series of N-Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) dione have been derived by the reaction of different substituted amino acids with phthalic anhydride to yield 2-(substituted) 1H-isoindole-1,3(2H) diones (3), further condensation with o-phenylenediamine yields 2substituted benzimidazolyl 1H-isoindole-1,3(2H) diones (4), followed mannich reaction with methanal and different amines to yields final products (5). The chemical structures of synthesized N-Mannich bases were determined by elemental analysis and spectral data (FTIR & 1 H NMR). All the synthesized derivatives have been evaluated for their antimicrobial, anthelmintic and insecticidal activities against microbes, helminthes and insects selected as compared to standard drugs by using disc diffusion method and Watkins technique respectively. All the synthesized N-Mannich bases possess the significant antimicrobial, anthelmintic and insecticidal activities.
In an attempt to find a new class of anti microbial agents, a series of thiazolidinone and their 5-arylidene derivatives containing 4-(4-methyl benzamido)-benzoyl moiety were synthesized via the reaction of benzocaine with appropriate chemical reagents. These compounds were screened for their antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Bacillus thuringiensis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and antifungal activity against Botrytis fabae, Fusarium oxysporan and Candida albicans. On the other hand the synthesized compounds were also screened for their anti tubercular activity. IR, 1 H NMR,
13C NMR and MS spectral analyses established the structures of the newly synthesized compounds. The results revealed that some of these compounds have shown promising antimicrobial and anti tubercular activity in comparison with standard drugs.
A series of compounds were synthesized from 3,3'-(pyridine-2,6-diyl) bis (2-phenylthiazolidin-4-one(1), which was prepared from a one-pot three component condensation reaction of 2, 6-diamino pyridine, benzaldehyde and thioglycolic acid in the presence of γ-ferrite as a catalyst. The newly synthesized compounds were characterized by IR,1HNMR,13C NMR spectral data. All compounds were tested for anti bacterial and anti fungal activities.
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