An environmentally benign protocol is described for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and N-fused 1,2,4-triazoles via ceric ammonium nitrate catalyzed oxidative cyclization of amidrazones and aldehydes using polyethylene glycol as recyclable reaction medium. This protocol is effective toward various substrates having different functionalities. The easy recyclability of the reaction medium makes the process economic and potentially viable for commercial applications.
Medium. -The high-yielding reaction succeeds using various aryl, hetaryl, and alkyl aldehydes, but fails with 4-nitrophenylaldehyde. The solvent, polyethylene glycol, is reused three times with only slightly decreasing reaction yields. -(NAKKA, M.; TADIKONDA, R.; RAYAVARAPU, S.; SARAKULA, P.; VIDAVALUR*, S.; Synthesis 47 (2015) 4, 517-525, http://dx.
The present paper deals with the ethno-medico-botany of Srikakulam district of Andhra Pradesh. 20 plant species belonging to 15 families are enumerated with knowledge of tribals for their medicinal uses in curing malaria. Plant part used, vernacular name, method of preparation of the drug and the dose of administration are given.
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