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IN-105 absorption is proportional to the dose administered. The 2-h postprandial glucose excursion was reduced in a dose proportional manner. Circulating C-peptide levels were found to be suppressed in proportion to the IN-105 exposure. IN-105 reduces glucose excursion despite lower endogenous insulin secretion. IN-105 seems to have a wide therapeutic window as no clinical hypoglycaemia was observed at any of the doses studied.

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The formation of this compound involves hydrolysis of an acetoxy group and subsequent lactonization, as well as removal of the side chain. The same compound is formed on hydrolysis of cephalosporin Cc. 4. Hydrolysis of cephalosporin CA (pyridine) in dilute acid yields the nucleus of cephalosporin CA (pyridine). This nucleus is also formed when 7aminocephalosporanic acid reacts with aqueous pyridine. We are indebted to Mrs M. Loveridge, Miss M. Arber and Miss 0. Breitenmoser for skilful technical assistance. We wish to thank the Lilly Research Laboratories and Merck Sharp and Dohme Inc. for gifts of 6-aminopenicillanic acid, and Dr M. R. Pollock for purified penicillinase.