The authors report a two-color, colocated quantum dot based imaging system used to take multicolor images using a single focal plane array (FPA). The dots-in-a-well (DWELL) detectors consist of an active region composed of InAs quantum dots embedded in In.15Ga.85As quantum wells. DWELL samples were grown using molecular beam epitaxy and fabricated into 320×256 focal plane arrays with indium bumps. The FPA was then hybridized to an Indigo ISC9705 readout circuit and tested. Calibrated blackbody measurements at a device temperature of 77K yield midwave infrared and long wave infrared noise equivalent difference in temperature of ∼55 and 70mK.
5519 Background: EGFR, a membrane tyrosine kinase receptor that regulates multiple functions such as cell growth, differentiation, gene expression and development through at least 3 pathways, is overexpressed in a wide variety of solid tumors, including CC. The downstream activation of the EGFR pathways has not been studied extensively. The aim of this study is to assess the correlation between EGFR-HER-2-HER-3-HER-4 status, downstream pathways (STAT 3, survivin, RAS) with pt characteristics, overall survival and recurrence free survival in pts diagnosed with invasive CC. Methods: Receptor expressions were assessed by immunohistochemistry on 80 pts from our clinic. Tumors were scored by percentage of cells stained multiplied by intensity for a score range of 0–300 by two pathologists. Median EGFR score was 140. Pts were categorized as low expressor (EGFR score lower than 140) or as high expressor (EGFR score greater than 140). Differences in receptor expression were compared using the Log-rank test for overall (OS) and recurrence-free survivals (RFS) and by Chi-square analyses for the clinical parameters (age, stage, histology, and grade). Results: A total of 80 pts data was analyzed. Mean age of the sample was 48 years. 23% of pts had well differentiated tumors. 80% had squamous histology. 39% had stage IIB or higher. 25% died of cancer. By Log-rank test, standard prognostic factors (age, stage, grade, and histology) showed the expected differences in survival, confirming the validity of the sample. However there were no correlations between the clinical parameters, OS, or RFS with EGFR expression. Data on HER-2–3-4, STAT3, survivin and RAS will be presented at the meeting. Conclusions: Although no correlation has been found between clinical outcome and EGFR expression, EGFR inhibitors of the extracellular domain are expected to be useful for the treatment of CC that overexpress this receptor. These results will serve as baseline data needed to test cetuximab and other EGFR inhibitors in pts with CC. No significant financial relationships to disclose.
Optimization of various growth parameters for Type-II GaSb(10MLs)/InAs(10MLs) nanoscale superlattices (SL) and GaSb layers, grown by solid molecular beam epitaxy, has been undertaken. We present optical and structural characterization for these heterostructures, using high resolution X-ray diffraction (HRXRD), photoluminescence (PL) and atomic force microscopy (AFM). Optimized parameters were then used for growth of InAs/GaSb SLs photovoltaic detectors (λ cut-off ~5 µm) operating at room temperature. By controlling the nature of interfaces, the in-plane mismatch between GaSb-buffer layer and SLs can be reduced enabling the growth of active regions up to 3µm. Normal incidence single pixel photodiodes were fabricated using standard lithography with apertures ranging from 25-300 µm in diameter. The spectral response from the SLs detector was observed at room temperature. This suggests the potential of the SLs technology for realizing high operating temperature (HOT) sensors. Responsivity measurements were also undertaken using a calibrated black body source, 400Hz optical chopper, SR 770 FFT Network signal analyzer and Keithley 428 preamplifier. We obtained current responsivity equal 2.16 A/W at V = -0.3V(300K). The Johnson noise limited D* at 300K was estimated to be 4.6 ×10 9 cm⋅Hz 1/2 /W at V = -0.3V
A sequential treatment with capecitabine followed by cisplatin and irinotecan is well tolerated and demonstrates clinical activity in patients with advanced solid malignancies. The influence of capecitabine, if any, on the efficacy of the cisplatin-irinotecan combination is not related to a variation in cisplatin-DNA adducts.
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