SummaryAn attempt has been made to determine what association, if any, exists between chronic dyspepsia and the presence of gall-stones, determined radiologically in women aged 50-70 years.The survey was conducted in a general practice to avoid the selection inevitable in a hospital population.The women were interviewed before being x-rayed, so that their histories were not biased by any knowledge of whether gall-stones were present or not.A history of dyspepsia was obtained from 12 (50%) out of 24 subjects with gall-bladder disease. Of those with normal cholecystograms 63 (53%) out of 118 had similar symptoms.The dyspepsia suffered by those with gall-stones was not distinguishable from that experienced by those with normal gall-bladders.It is concluded that among women aged between 50 and 70 the occurrence of chronic dyspepsia and gall-bladder disease is coincidental. These symptoms cannot assist in diagnosis of gall-bladder disease and should not influence its treatment.I am grateful to Dr. E. B. French for suggesting this inquiry and for helpful criticism; to Dr. R. C. McNair for enlisting the co-operation of his patients; to Mr. S.

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