Effects of Growth Hormone on Calcium and Magnesium Metabolism

Hanna, S; Harrison, Mike T.; MacIntyre, I.; Fraser, Russell

doi:10.1136/bmj.2.5243.12

Cited by 47 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Growth hormone appears to exert an effect on the renal handling of cal cium and magnesium which is opposite to that of parathyroid hormone; thus, the administration of growth hormone results in increased urinary excretion of calcium and magnesium [93,101,109,114], This effect of growth hormone may have clinical significance in that patients with acromegaly often show hypercalciuria and may develop renal stones, presumably related in part to this renal effect [16,54,94]. Since the serum calcium level is not affected by growth hormone, the renal effect of the hormone is presumably related to altered tubular reabsorption of these divalent cations.…”

Section: Growth Hormonementioning

confidence: 99%

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Massry¹,

Jw²

1973

Nephron

View full text Add to dashboard Cite

This report reviews the various hormonal and non-hormonal factors involving the renal handling of calcium and magnesium and the effect of these factors on the relationship between the excretions of these divalent ions and that of sodium. Among the factors discussed are: (1) extracellular volume expansion, (2) renal vasodilatation, (3) changes in glomerular filtration rate, Parathyroid hormone (4) hypercalcemia and hypermagnesemia, (5) diuretics, (6) phosphate depletion and loading, (7) alterations in acid base balance, (8) diet, (9) fasting, (10) activity, (11) diurnal variation, and (12) various hormones including parathyroid hormone, calcitonin, vitamin D, growth hormone, thyroid hormone, and adrenal steroids.

show abstract

Section: Growth Hormonementioning

confidence: 99%

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Massry¹,

Jw²

1973

Nephron

View full text Add to dashboard Cite

show abstract

“…Forbes et al [10] reported a "slight" decrease in one subject, and no change in a second. Hanna et al [13] also found a slight decrease. Elsair et al [6] studied four children; fecal Ca decreased in one subject and increased in one, while the other two showed an insignificant change.…”

Section: Discussionmentioning

confidence: 81%

“…In addition to having been observed in children with GH deficiency, hypercalcuria has been noted in normal children and adults, and in patients with such diverse conditions as Turner's syndrome [10], acromegaly [22], primordial dwarfism [39], dwarfism with elevated plasma GH levels (Laron dwarfs) [21], resistant rickets, renal osteodystrophy [16], and osteoporosis [13,30]. However, Vest et al [36] found hypercalcuria in only half of the normal infants whom they studied; Villee et al [37] failed to find it in one child with progeria, as did Root and Oski [27] in two of three senile adults.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

et al. 1972

View full text Add to dashboard Cite

ExtractThe effect of human growth hormone (GH) administration (5 mg daily) was studied in 12 children with short stature, in an attempt to elucidate the cause of the hypercalcuria which so commonly occurs at the initiation of GH therapy. Complete metabolic balances were determined for Ca, P, N, Na, K, and Cl; and urine was analyzed for hydroxyproline, stable Sr, Pb, Mg, 137 Cs, F, and creatinine. Some subjects had determinations of basal metabolic rate (BMR) and of ultrafiltrable serum Ca. In keeping with the reports of others, levels of N, P, K, Na, and Cl in urine all declined, as did that of 187 Cs; Mg excretion fell slightly. Ten of the 12 children with short stature (6 of whom had subnormal plasma GH responses to a variety of stimuli) had hypercalcuria; 3 of these had an increase in urine Ca in the face of a low Ca diet (170 mg/24 hr). Fecal Ca declined in some subjects and rose in others. Ultrafiltrable serum Ca did not change.A majority of the subjects showed an increase in the urinary excretion of F, Sr, Pb, and hydroxyproline.The effect of the hormone was also studied in three patients with idiopathic hypoparathyroidism; two of these responded with an increase in urine Ca.The magnitude of the rise in urine Ca could not be correlated with changes in BMR, changes in creatinine clearance, or changes in Na excretion; it was positively correlated with the increases in Sr and Pb in urine. SpeculationWe have evidence that the hypercalcuria accompanying GH administration is not due to increased gastrointestinal absorption, alterations in serum Ca, or changes in metabolic rate or renal function; nor is it mediated via parathyroid activity. These considations, plus the fact that the hypercalcuria is accompanied by hydroxyprolinuria and an increase in the urinary excretion of three "bone seekers" (Sr, Pb, and F), lead us to postulate that the hormone enhances bone resorption, either per se or via "sulfation factor."

show abstract

“…Secondly, successful treatment with bromocriptine causes a reduction in urinary Ca excretion after a few months (Eskildsen et al 1978). Finally, the hypercalciuria which follows GH treatment becomes evident only after a few days of treatment in normal man (Ikkos et al 1959;Hanna et al 1961). It is most unlikely that gross anatomical changes are responsible for these changes in uri¬ nary Ca excretion.…”

Section: Discussionmentioning

confidence: 97%

Urinary 3',5'-cyclic adenosine monophosphate in relation to serum and urinary calcium in acromegaly and primary hyperparathyroidism

Halse

1980

Acta Endocrinologica

View full text Add to dashboard Cite

A comparison of the interrelations between serum and urinary calcium values and the urinary excretion of cAMP in acromegaly (No. of subjects: 26), patients with primary hyperparathyroidism (n = 18) and control subjects (n = 42) is presented.The cAMP excretion was greatest in primary hyperparathyroidism, but acromegalics also exhibited higher values for this parameter than controls. A positive correlation was found between serum calcium values and cAMP in primary hyperparathyroidism, while acromegalics showed no correlation between these parameters. In controls there was a negative correlation between serum calcium and cAMP. Serum calcium levels corrected for variations in total protein concentrations were elevated both in acromegaly and primary hyperparathyroidism, mostly in the latter. Acromegalics and patients with primary hyperparathyroidism exhibited an increase in 24 h calcium excretion.While there was a negative relationship between urinary calcium excretion and cAMP in acromegaly, a positive correlation between these parameters was found in primary hyperparathyroidism. Controls showed a negative correlation between urinary calcium values and cAMP. It is concluded that the role of the parathyroids in the regulation of calcium metabolism in acromegaly is different from that of both normal controls and primary hyperparathyroidism. It is postulated that an active form of Vitamin D plays a major role in the regulation of calcium metabolism in acromegaly.

show abstract

Effects of Growth Hormone on Calcium and Magnesium Metabolism

Cited by 47 publications

References 11 publications

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

Urinary 3',5'-cyclic adenosine monophosphate in relation to serum and urinary calcium in acromegaly and primary hyperparathyroidism

Contact Info

Product

Resources

About