Urinary 3',5'-cyclic adenosine monophosphate in relation to serum and urinary calcium in acromegaly and primary hyperparathyroidism

Halse, Johan

doi:10.1530/acta.0.0940468

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Scand 3,4,8,10,18,231. This is due to the fact that [NCAMPI(;~ is obtained as the difference [UCAMPI(:~ -[CAMP], where both terms are subject to a considerable analytical variation.…”

Section: Discussionmentioning

confidence: 99%

Serum ionized calcium, nephrogenous and total urinary cyclic AMP and urinary phosphate in normal subjects

Thode

Siggaard‐Andersen

1984

Scandinavian Journal of Clinical and Laboratory Investigation

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Total urinary cyclic AMP (UcAMP) and nephrogenous cyclic AMP (NcAMP) were measured in 4, 20 and 24 h urine in forty-eight healthy volunteers. There were no significant differences between 4, 20 and 24 h excretion rate of UcAMP and NcAMP whether it was corrected for the glomerular filtration rate [( UcAMP]GF, [NcAMP]GF), creatinine corrected (UcAMP/Crea)U, or expressed as actual excretion rate (NcAMP,n), nor any sex differences. Mean values +/- one standard deviation (SD) for these parameters: [UcAMP]GF: 30.4 +/- 9.4 nmol/l; 27.7 +/- 7.0 nmol/min; 28.1 +/- 6.9 nmol/l in 4, 20 and 24 h urine, respectively. [NcAMP]GF: 13.4 +/- 8.5 nmol/l; 10.6 +/- 7.7 nmol/l; and 11.1 +/- 7.2 nmol/l in 4, 20 and 24 h urine, respectively. (NcAMP,n): 1.45 +/- 0.90 nmol/min; 1.14 +/- 0.80 nmol/min; 1.17 +/- 0.73 nmol/min in 4, 20 and 24 h urine, respectively, NcAMP accounts for about 40% of UcAMP. A positive correlation was found between plasma cyclic AMP and [UcAMP]GF (r = 0.41, P less than 0.001), whereas this relationship could not be demonstrated between plasma cyclic AMP and [NcAMP]GF (r = -0.008, P greater than 0.1). The calculation of [NcAMP]GF therefore corrects for unsuspected high or low plasma cyclic AMP values, and is therefore the preferred parameter of the PTH effect on the kidney tubular cells. No correlation could be demonstrated between [NcAMP]GF and concentration of ionized calcium in plasma.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Scand 3,4,8,10,18,231. This is due to the fact that [NCAMPI(;~ is obtained as the difference [UCAMPI(:~ -[CAMP], where both terms are subject to a considerable analytical variation.…”

Section: Discussionmentioning

confidence: 99%

Serum ionized calcium, nephrogenous and total urinary cyclic AMP and urinary phosphate in normal subjects

Thode

Siggaard‐Andersen

1984

Scandinavian Journal of Clinical and Laboratory Investigation

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“…In acromegaly there is an increase in parathyroid function (Halse & Haugen 1980;Halse 1980) and in the serum levels of the ultimate active vitamin D metabolite, 1.25-dihydroxyvitamin D (Eskildsen et al 1979;Brown et al 1980). How these secondary changes in the main hormones regulating calcium-phos¬ phorus metabolism affect bone remodelling in acromegaly is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The urine was analyzed for total and non-dialyzable hydroxyproline Halse & Gordeladze 1981) as well as calcium, phosphate and creatinine. Urinary 3',5'-cyclic adenosine monophosphate (cAMP) was measured using a competitive protein binding me¬ thod (kit from the Radiochemical Centre, Amersham, England) (Halse & Gordeladze 1979;Halse 1980).…”

Section: Methodsmentioning

confidence: 99%

Iliac crest bone mass and remodelling in acromegaly

Halse¹,

Melsen²,

Mosekilde³

1981

Acta Endocrinologica

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Iliac crest bone biopsies from 18 patients with active acromegaly, of whom 11 had received tetracycline double-labelling, were evaluated by quantitative histomorphometry and compared with age-and sex-matched normal controls. A significant increase (P<0.01) was found in both cortical (175%) and trabecular (130%) bone mass. In trabecular bone, resorption surfaces and active (tetracycline-labelled) and total formation surfaces were increased (P < 0.05 and P<0.01, respectively) causing an enhanced bone turn-over at tissue level (P < 0.01). The increased trabecular bone mass indicates a positive net balance per remodelling cycle and, therefore, larger than normal bone remodelling units, which in part may explain the increased bone turn-over at tissue level. The activity of the osteoblasts active in mineralization (the appositional rate) was increased (P<0.01) and positively related to the fasting serum growth hormone levels (Rs = 0.69, P < 0.05). The average activity of active and inactive osteoblasts (bone formation rate at basic metabolic unit (BMU) level) was insignificantly increased. The proportion of active (tetracycline labelled) to non\x=req-\ active formation surfaces was normal. The bone changes were unrelated to serum levels and urinary excretions of calcium and phosphorus or to renal excretion of total and non-dialyzable hydroxyproline or cAMP.The metabolic bone disease of acromegaly has over the years been the subject of repeated discussion. Radiological investigations have shown a coarsen¬ ing of trabecular patterns and increased radiolucency -especially of the vertebral bodies. This finding was interpreted by earlier investigators as evidence for osteoporosis (Scriver & Bryan 1935; Albright & Reifenstein 1948). A recent prestigious textbook also links acromegaly with osteoporosis (Avioli & Raisz 1980). Erdheim (1931) observed that in spite of radio¬ logical evidence of osteoporosis, the surface-near trabecular structures of the vertebral bodies were often thicker than normal. Consequently, he called the bone affection in acromegaly a 'sclerosing osteoporosis '. Remagen (1965) demonstrated that an increase in trabecular size could also be demon¬ strated in other parts of the skeleton.Recently the concept of osteoporosis in acro¬ megaly has been challenged. Doyle (1967) and Ikkos et al. (1974) using x-ray morphometry have demonstrated that the bone mass is actually in¬ creased in these patients. Using histomorphometry, Roelfsma et al. (1970) found increased values both for cortical and trabecular bone masses -results which were corroborated by Riggs et al. (1972) who studied a number of patients by bone densitometry and microradiography. Erdheim (1931) pointed to the increase in periosteal and enchondreal bone formation occur¬ ring in acromegaly. Riggs et al. (1972) and Delling & Schulz (1977) have presented evidence based on measurements of trabecular bone for an increase in bone turn-over. So far only one case report (Ramser et al. 1966) has described bone dynamics in acromegaly as evaluated after do...

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“…The urinary excretion of 3',5'-cyclic adenosine monophosphate (cAMP) was used as an estimate of para¬ thyroid function (Kaminsky et al 1970;Halse & Gorde¬ ladze 1979;Halse 1980) and measured by a competitive protein binding method (kit from The Radiochemical Corp., Amersham, England).…”

Section: Methodsmentioning

confidence: 99%

Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects

Halse

Gordeladze

1981

Acta Endocrinologica

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The urinary excretion of total and non-dialyzable hydroxyproline (HYP) containing peptides has been studied in 25 patients with active acromegaly and 44 control subjects -all kept on a collagen free diet. Acromegalics had a greater excretion of both total and non-dialyzable HYP than controls, indicating an increased turn-over of collagen/bone matrix. The amounts of total and non-dialyzable HYP excreted in acromegalics were significantly correlated to mean fasting growth hormone levels. Both acromegalics and controls exhibited a significant coupling between the excretion of total and non-dialyzable HYP. Female control subjects demonstrated an age-dependent decrease in the excretion of both total and non-dialyzable HYP, whereas no such age-dependence could be observed in males. Age seemed to have a greater effect on the non-dialyzable fraction than on the total HYP excretion. These results may imply that collagen/bone matrix turn\x=req-\ over declines with age and that bone formation declines at a more rapid rate than resorption. In acromegalics the ratio of non-dialyzable to dialyzable HYP was not significantly different from control values, indicating that although turn-over is increased the actual matrix formation rate is normal in acromegaly. No correlation was found between serum or urinary parameters of calcium/phosphate metabolism or the urinary excretion of 3',5'-cyclic adenosine monophosphate and total or non-dialyzable HYP in acromegalics or controls.

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Urinary 3',5'-cyclic adenosine monophosphate in relation to serum and urinary calcium in acromegaly and primary hyperparathyroidism

Cited by 4 publications

References 14 publications

Serum ionized calcium, nephrogenous and total urinary cyclic AMP and urinary phosphate in normal subjects

Serum ionized calcium, nephrogenous and total urinary cyclic AMP and urinary phosphate in normal subjects

Iliac crest bone mass and remodelling in acromegaly

Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects

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