Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects

Halse, Johan; Gordeladze, Jan O.

doi:10.1530/acta.0.0960451

Cited by 25 publications

(12 citation statements)

References 15 publications

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“…The ratios of NDHP and FHP to THP resembled those described earlier (Laitinen, 1974;Skogland et al, 1981;Halse and Gordeladze, 1981). In an earlier investigation (Autio, 1972) THP excretion in a material of 12 AGU patients (of which three were children) was reported to be normal.…”

Section: Age(years)supporting

confidence: 83%

“…The proportion of NDHP or FHP of total hydroxyproline (THP) shows no dramatic alteration during growth (Kivirikko, 1970;Laitinen, 1974; Skoglund et al, 1981). THP excretion and the ratios between the hydroxyproline fractions have been suggested to reflect the turnover rate of collagen (Skoglund et al, 1981;Halse and Gordeladze, 1981) and were used in the present study to investigate collagen turnover in vivo in AGU patients. …”

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confidence: 99%

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Metabolism of collagen in aspartylglycosaminuria: Urinary excretion of hydroxyproline

Näntö‐Salonen

Autio²,

Haro³

et al. 1984

J of Inher Metab Disea

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Aspartylglycosaminuria (AGU) is a lysosomal storage disorder of glycoprotein degradation characterized by severe mental retardation and connective tissue alterations. We have previously described low collagen production in skin fibroblast cultures from AGU patients. In the present work we showed that the urinary excretion of hydroxyproline (total, non-dialysable and free hydroxyproline as indicators of collagen metabolism) was reduced in young AGU patients in comparison with age-matched controls. In adult patients no significant difference was detected. The results support the view that reduced collagen production is associated with the connective tissue abnormalities in this disorder.

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Section: Age(years)supporting

confidence: 83%

mentioning

confidence: 99%

Metabolism of collagen in aspartylglycosaminuria: Urinary excretion of hydroxyproline

Näntö‐Salonen

Autio²,

Haro³

et al. 1984

J of Inher Metab Disea

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“…This enhan¬ ced bone turnover at tissue level is in accordance with kinetic studies of skeletal calcium exchange rates in acromegalic patients (Eisenberg & Gordan 1961). The significant positive correlations found between serum levels of GH and bone remodelling estimated by microradiography on one hand (Riggs et al 1972) and urinary excretion of hydroxyproline on the other (Halse 8c Gordeladze 1978, 1981, indicate that the effect of GH on bone turnover is proportional to the serum concentra¬ tion of the hormone. The increase in formation rate at tissue level may in part be explained by larger packets.…”

Section: Discussionmentioning

confidence: 97%

“…All patients re¬ ceived a collagen free diet for 3 days and two 24 h urine portions were sampled from the second day on. The urine was analyzed for total and non-dialyzable hydroxyproline Halse & Gordeladze 1981) as well as calcium, phosphate and creatinine. Urinary 3',5'-cyclic adenosine monophosphate (cAMP) was measured using a competitive protein binding me¬ thod (kit from the Radiochemical Centre, Amersham, England) (Halse & Gordeladze 1979;Halse 1980).…”

Section: Methodsmentioning

confidence: 99%

Iliac crest bone mass and remodelling in acromegaly

Halse¹,

Melsen²,

Mosekilde³

1981

Acta Endocrinologica

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Iliac crest bone biopsies from 18 patients with active acromegaly, of whom 11 had received tetracycline double-labelling, were evaluated by quantitative histomorphometry and compared with age-and sex-matched normal controls. A significant increase (P<0.01) was found in both cortical (175%) and trabecular (130%) bone mass. In trabecular bone, resorption surfaces and active (tetracycline-labelled) and total formation surfaces were increased (P < 0.05 and P<0.01, respectively) causing an enhanced bone turn-over at tissue level (P < 0.01). The increased trabecular bone mass indicates a positive net balance per remodelling cycle and, therefore, larger than normal bone remodelling units, which in part may explain the increased bone turn-over at tissue level. The activity of the osteoblasts active in mineralization (the appositional rate) was increased (P<0.01) and positively related to the fasting serum growth hormone levels (Rs = 0.69, P < 0.05). The average activity of active and inactive osteoblasts (bone formation rate at basic metabolic unit (BMU) level) was insignificantly increased. The proportion of active (tetracycline labelled) to non\x=req-\ active formation surfaces was normal. The bone changes were unrelated to serum levels and urinary excretions of calcium and phosphorus or to renal excretion of total and non-dialyzable hydroxyproline or cAMP.The metabolic bone disease of acromegaly has over the years been the subject of repeated discussion. Radiological investigations have shown a coarsen¬ ing of trabecular patterns and increased radiolucency -especially of the vertebral bodies. This finding was interpreted by earlier investigators as evidence for osteoporosis (Scriver & Bryan 1935; Albright & Reifenstein 1948). A recent prestigious textbook also links acromegaly with osteoporosis (Avioli & Raisz 1980). Erdheim (1931) observed that in spite of radio¬ logical evidence of osteoporosis, the surface-near trabecular structures of the vertebral bodies were often thicker than normal. Consequently, he called the bone affection in acromegaly a 'sclerosing osteoporosis '. Remagen (1965) demonstrated that an increase in trabecular size could also be demon¬ strated in other parts of the skeleton.Recently the concept of osteoporosis in acro¬ megaly has been challenged. Doyle (1967) and Ikkos et al. (1974) using x-ray morphometry have demonstrated that the bone mass is actually in¬ creased in these patients. Using histomorphometry, Roelfsma et al. (1970) found increased values both for cortical and trabecular bone masses -results which were corroborated by Riggs et al. (1972) who studied a number of patients by bone densitometry and microradiography. Erdheim (1931) pointed to the increase in periosteal and enchondreal bone formation occur¬ ring in acromegaly. Riggs et al. (1972) and Delling & Schulz (1977) have presented evidence based on measurements of trabecular bone for an increase in bone turn-over. So far only one case report (Ramser et al. 1966) has described bone dynamics in acromegaly as evaluated after do...

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“…In fact, several studies have suggested a growth hormone (GH)-mediated increase of bone turnover in acromegaly based on the evaluation of biochemical markers, calcium kinetics, and bone histomorphometry [17][18][19][20]. However, the data on PTH behavior in acromegaly are not consistent, suggesting that these values may be normal or slightly increased at the diagnosis of disease [21][22][23][24] and they may also change during the medical treatment with somatostatin analogs [23] these data were obtained with a bcrudeQ measure of PTH secretion, whereas data on PTH pulsatility in acromegaly have not been so far reported.…”

Section: Introductionmentioning

confidence: 99%