Metabolism of collagen in aspartylglycosaminuria: Urinary excretion of hydroxyproline

Näntö‐Salonen, Kirsti; Autio, S.; Haro, Expedito N.; Kivimäki, T.; Koskela, Sirkka-Liisa; Nántö, V.; Penttinen, Risto

doi:10.1007/bf01801767

Cited by 5 publications

(2 citation statements)

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“…The villi lamina propia core is mainly composed of connective tissue (Udenfriend 1966); therefore damage to ileal villi and its connective tissue could result in collagen leakage into ileal lumina and degradation into constituent components like T4HP. Breakdown of collagen would explain T4HP in urine of A mice consistent with rat and human studies reporting increased urinary T4HP in collagen breakdown from other causes (Näntö-Salonen et al 1984, Prockop and Sjoerdsma 1961; Anasuya and Rao 1970). T4HP may serve as a useful marker of intestinal necrosis in NEC in preterm infants and in other childhood inflammatory bowel diseases.…”

Section: Resultssupporting

confidence: 77%

“…Correspondingly, the p-value for 14 out of the 15 T4HP-associated buckets were 10 −4 or smaller. T4HP is a breakdown product of collagen (Näntö-Salonen et al 1984) found largely in connective tissue (Udenfriend 1966). The villi lamina propia core is mainly composed of connective tissue (Udenfriend 1966); therefore damage to ileal villi and its connective tissue could result in collagen leakage into ileal lumina and degradation into constituent components like T4HP.…”

Section: Resultsmentioning

confidence: 99%

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Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

et al. 2013

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Metabolic profiling of urine and fecal extracts, histological investigation of intestinal ilea, and fecal metagenomics analyses were used to investigate effects of prolonged antibiotic use in mice. The study provides insight into the effects of extended empiric antibiotic therapy in humans. Mice were administered a broad-spectrum antibiotic for four consecutive days followed by oral gavage with Clostridium butyricum, an opportunistic gram-positive pathogenic bacteria commonly isolated in fecal and blood cultures of necrotizing enterocolitis patients. Metagenomics data indicated loss of bacterial diversity after 4 days on antibiotics that was restored after removing antibiotic pressure. Histological analyses indicated damage to ileal villi after antibiotic treatment that underwent repair after lifting antibiotic pressure. Metabolic profiling confirmed intestinal injury in antibiotic-treated mice indicated by increased urinary trans-4-hydroxy-l-proline, a breakdown product of collagen present in connective tissue of ileal villi that may serve as a biomarker for antibiotic-induced injury in at risk populations.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

et al. 2013

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Disturbed metabolism of copper and zinc in aspartylglycosaminuria: Possible involvement with connective tissue changes

Näntö‐Salonen

Halme

Penttinen

et al. 1984

J of Inher Metab Disea

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In aspartylglycosaminuria (AGU), a lysosomal storage disorder of glycoprotein degradation, there are some abnormalities in collagen and proteoglycan metabolism. Because of earlier observations suggesting a disturbance of copper balance, the metabolism of copper and zinc was studied in more detail to find out if possible trace metal disturbances could be correlated with connective tissue disorder. Highly elevated copper concentrations in the hair and significantly reduced zinc levels in serum and urine were detected in AGU patients indicating a disturbance of trace element balance. However, the patients had normal serum copper levels, and the concentrations of zinc and copper in cultured fibroblasts did not differ from those of control cells. Normal lysyl oxidase activities in cell culture indicate that collagen cross-link formation is not affected. The changes in copper and zinc balance are probably secondary to the basic enzyme deficiency, and may contribute to the development of the clinical signs and symptoms of AGU although the mechanisms involved are not yet understood.

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Ascorbate regulation of collagen biosynthesis in Ehlers-Danlos syndrome, type VI

Dembure¹,

Janko²,

Priest³

et al. 1987

Metabolism

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Metabolism of collagen in aspartylglycosaminuria: Urinary excretion of hydroxyproline

Cited by 5 publications

References 13 publications

Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

Disturbed metabolism of copper and zinc in aspartylglycosaminuria: Possible involvement with connective tissue changes

Ascorbate regulation of collagen biosynthesis in Ehlers-Danlos syndrome, type VI

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