Magnesium Metabolism in Parathyoid Disease

Hanna, S; North, K. A. K.; MacIntyre, I.; Fraser, Russell

doi:10.1136/bmj.2.5262.1253

Cited by 61 publications

(19 citation statements)

References 7 publications

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“…This vitamin D effect on urinary magnesium was less marked in Hanna's studies (3) and was not seen in those of Richardson and Welt (4). In the experiments of these investigators the comparison was between rats receiving "ordinary" amounts of vitamin D and those given massive doses.…”

Section: Discussioncontrasting

confidence: 48%

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Effects of Vitamin D on Magnesium Metabolism in Rats¹

Lifshitz

Harrison

1967

Endocrinology

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The effect of a single dose of 5000 IU of vitamin D on the concentrations of magnesium in serum and bone and the excretion of magnesium in urine of vitamin D-deficient rats fed either a magnesium-deficient or control diet was determined. Vitamin D treatment caused a more rapid decrease of bone and serum magnesium concentrations of rats placed on a low magnesium diet. Urinary magnesium excretion was higher in the vitamin D-treated rats. This effect was seen in rats fed the magnesium-containing control diet as well as the magnesiumdeficient ration. The effect of vitamin D in increasing the renal clearance of magnesium is opposite to that of parathyroid hormone. This may indicate a separate action of vitamin D on renal tubular function or an inhibition of parathyroid hormone output by vitamin D. (Endocrinology 81: 849,1967) I N 1930, McHargue and Roy (1) found that the carcass magnesium content of rats subjected to ultraviolet irradiation was less than that of control animals. Subsequently, it has also been observed that vitamin D administration reduces serum magnesium concentrations in the rat (2-5), in the dog (6) and in man (7).The mechanism whereby vitamin D reduces the concentration of serum magnesium was studied by Hanna (3), who found that intramuscular administration of large doses of vitamin D increased urinary magnesium excretion despite hypomagnesemia. Richardson and Welt (4), however, did not find a significant effect of vitamin D on urinary or fecal magnesium excretion, nor was there a significant change in their experiments in the concentrations of total carcass and muscle magnesium after the subcutaneous injections of large amounts of vitamin D 2 .In the above studies the effects of ]arge doses of vitamin D on the magnesium metabolism of rats were measured in comparison with findings in control animals fed a normal vitamin D ration. The serum magnesium concentration of rats given physiologic doses of vitamin D is less than that of vitamin D-deficient rats (5).In order to determine the effects of physiologic amounts of vitamin D on magnesium metabolism, the serum, bone and urine magnesium concentrations of vitamin Ddeficient rats were studied after the administration of a single dose of vitamin D in conjunction with either a low magnesium or a control magnesium-containing diet. Materials and MethodsMale Sprague-Dawley rats from dams deprived of vitamin D during lactation were randomly divided into groups at weaning. They were given a vitamin D-free, magnesium-containing diet that has been described in detail elsewhere (5). After 2 weeks on this diet half the rats were given 5000 IU of vitamin D 2 orally. Twenty-four hr after this vitamin D treatment the vitamin D-deficient and the vitamin Dtreated groups of rats were each divided into 2 subgroups: one was fed a magnesium-deficient diet and the other continued on the control magnesium-containing diet. There were then 4 groups of animals: vitamin D-treated control and magnesium deficient, and vitamin D-deficient control and magnesium deficient. Rats f...

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Section: Discussioncontrasting

confidence: 48%

“…Subsequently, it has also been observed that vitamin D administration reduces serum magnesium concentrations in the rat (2)(3)(4)(5), in the dog (6) and in man (7).…”

Section: N 1930 Mchargue and Roymentioning

confidence: 96%

Effects of Vitamin D on Magnesium Metabolism in Rats¹

Lifshitz

Harrison

1967

Endocrinology

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“…Hypomagnesaemia has, however, occasionally been noted preoperatively in primary hyperparathyroidism, especially in association with very high plasma calcium concentrations (Harmon, 1956;Barnes et al, 1957;Agna and Goldsmith, 1958;Hanna et al, 1961). The low plasma magnesium concentration has usually been taken to indicate magnesium deficiency, which has been variously attributed to anorexia, to vomiting, and to obligatory urinary magnesium losses (Hanna et al, 1961;Heaton, 1966).…”

Section: Introductionmentioning

confidence: 99%

Plasma Magnesium Concentration in Primary Hyperparathyroidism

Sutton¹

1970

BMJ

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“…23,[29][30][31] In the series of studies on the regulation of magnesium homeostasis, the role of the PTH is obviously of primary interest. 32,33 Mg is essential for synthesis, release and tissue sensitivity to PTH. Similar to hypercalcemia, magnesium supplementation has been proven to be able to inhibit PTH synthesis and secretion.…”

Section: Discussionmentioning

confidence: 99%

Effect of parathyroid hormone on serum magnesium levels: the neglected relationship in hemodialysis patients with secondary hyperparathyroidism

Teng

Hou

et al. 2015

Renal Failure

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disturbance plays an important role in CKD-MBD and cardiovascular mortality, the interest on magnesium has grown recently. Although much concern focused on the effect of Mg on parathyroid hormone (PTH) levels, however, the influence of PTH on serum Mg levels is nearly unexplored. To evaluate the effect of PTH on serum Mg levels, we first described the relationship between serum Mg and PTH in secondary hyperparathyroidism. Besides, we also monitored the changes of serum Mg concentration after parathyroidectomy (PTX) in 23 patients. In our study, we found that hypermagnesemia (42.5 mg/dL) occurred in up to 44% of cases and hypomagnesemia did not present. No statistically signiEcant correlations were found between serum Mg levels and PTH (r ¼ À0.143, p ¼ 0.134). Correlation analysis and regression analysis suggested that the derangement of magnesium homeostasis was consistent with the derangement of calcium/phosphorus homeostasis. However, after PTX, serum magnesium levels dropped immediately after the surgery, minimally at the first day and gradually restored from the third day. The changes of serum Mg after surgery was positive correlated with the changes of serum phosphate (r ¼ 0.558, p ¼ 0.003). Taken altogether, our data suggested that the therapeutic strategies to achieve optimum serum magnesium levels in CKD-MBD should take into account the varying stages of disease development since PTH could also influence magnesium metabolism and this problem might be important in severe secondary hyperparathyroidism. KeywordsSerum magnesium, parathyroid hormone, secondary hyperparathyroidism, chronic kidney disease-mineral and bone disorder, parathyroidectomy History

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Magnesium Metabolism in Parathyoid Disease

Cited by 61 publications

References 7 publications

Effects of Vitamin D on Magnesium Metabolism in Rats¹

Effects of Vitamin D on Magnesium Metabolism in Rats¹

Plasma Magnesium Concentration in Primary Hyperparathyroidism

Effect of parathyroid hormone on serum magnesium levels: the neglected relationship in hemodialysis patients with secondary hyperparathyroidism

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Magnesium Metabolism in Parathyoid Disease

Cited by 61 publications

References 7 publications

Effects of Vitamin D on Magnesium Metabolism in Rats1

Effects of Vitamin D on Magnesium Metabolism in Rats1

Plasma Magnesium Concentration in Primary Hyperparathyroidism

Effect of parathyroid hormone on serum magnesium levels: the neglected relationship in hemodialysis patients with secondary hyperparathyroidism

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Effects of Vitamin D on Magnesium Metabolism in Rats¹

Effects of Vitamin D on Magnesium Metabolism in Rats¹