Central diabetes insipidus (CDI) - a severe disease with disturbance of arginine vasopressin secretion, with excretion of large
amounts of hypotonic urine, which leads to dehydration and thirst. Desmopressin, a synthetic analog of arginine vasopressin, is used to
compensate a water-electrolyte balance in patients with CDI is available in forms of intranasal spray and tablets. Herein we present a
clinical case of a patient with longstanding CDI due to Langerhans cell hystiocytosis in childhood who received different medications
for treatment of CDI symptoms that demonstrates variable efficiency and tolerance of these drugs.
Hypercortisolism is a severe endocrine disorder that leads to all types of metabolic disturbances. The most frequent symptom of hypercortisolism is a specific weight gain and body fat distribution - "cushingoid" obesity which clinically reflects the pathological changes in protein, carbohydrate and lipids metabolism. We provide a clinical case of a patient with Cushings disease. This clinical case represents challenges in the differential diagnosis of this rare endocrine disorder and metabolic syndrome, and specific approach in further evaluation and treatment of Cushing's disease that requires all the latest technology in this field to be employed.
Chronic fatigue syndrome is a disease of unexplained feeling of profound fatigue lasting for more than 6 months. This fatigue is
not relieved even after prolonged rest and is exacerbated after physical or mental work. More than 3000 scientific studies had proved that
chronic fatigue syndrome is not a form of depression or hypochondria. It is a real somatic illness that results in professional, social and
individual desadaptation. This article summarizes the contemporary etiological conceptions of this condition.
Genetic aspects of familial isolated pituitary adenomas (FIPA) are expanding rapidly in the last few years. Around 20% of these FIPA families have been identified to have mutations within the aryl hydrocarbon receptor interacting protein (AIP) gene. The number of identified AIP-positive FIPA families is increasing all over the world.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.