We investigated the effects of E. edulis bioproducts (lyophilized pulp [LEE], defatted lyophilized pulp [LDEE], and oil [EO]) on nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in rats. All products were chemically analyzed. In vivo, 42 rats were equally randomized into seven groups receiving standard diet, HFD alone or combined with EO, LEE, or LDEE. After NAFLD induction, LEE, LDEE, or EO was added to the animals' diet for 4 weeks. LEE was rich in polyunsaturated fatty acids. From LEE degreasing, LDEE presented higher levels of anthocyanins and antioxidant capacity in vitro. Dietary intake of LEE and especially LDEE, but not EO, attenuated diet-induced NAFLD, reducing inflammatory infiltrate, steatosis, and lipid peroxidation in liver tissue. Although both E. edulis bioproducts were not hepatotoxic, only LDEE presented sufficient benefits to treat NAFLD in rats, possibly by its low lipid content and high amount of phenols and anthocyanins.
this study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. the animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. the treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. the cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.
A sepse representa um evento mórbido de extrema importância do ponto de vista clínico e de saúde pública, atingindo milhares de pessoas anualmente, no mundo. De uma perspectiva imunológica, os macrófagos são células extremamente importantes na interação Homo sapiens sapiens/ bactérias, ainda que muitos aspectos da atuação dessas células permaneçam aguardando elucidação. O presente artigo apresenta os requerimentos para a simulação computacional do macrófago no sistema AutoSimmune, permitindo o desenvolvimento de estudos sobre o papel dessa célula na sepse. Artificial macrophages and the human immune system computational modeling for the investigation of sepsis pathophysiology: Perspectives Abstract Sepsis represents a morbid event of fundamental importance both from clinical and public health point of view, affecting thousands of people worldwide annually. From the immunological perspective, macrophages are extremely important cells in the interaction Homo sapiens sapiens / bacteria. However, several aspects concerning the action of these cells await elucidation. This paper presents the requirements for computational simulation of macrophage in the AutoSimmune system, allowing the development of studies on the role of this cell in sepsis.
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