Oxidative stress markers in cognitively intact patients with diabetic neuropathy

Etienne, Isaac; Magalhães, Lucas Vilas Bôas; Cardoso, Sílvia Almeida; Freitas, Rodrigo Barros; Oliveira, Guilherme Pereira de; Palotás, András; Lima, Luciana Moreira

doi:10.1016/j.brainresbull.2019.06.001

Cited by 17 publications

(14 citation statements)

References 31 publications

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“…Because of hypoxia in the endometrium, neuroischaemia, the loss of neurotrophic support, and neurological dysfunction are observed [34]. Studies have shown that a variety of mechanisms, such as adrenergic mechanisms, Na1 currents, opioid neurotransmission and oxidative stress, are involved in the neuropathic pain response in DPN [35][36][37]. In recent years, many researchers have focused on oxidative stress in peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

Jin-hong

Tian

et al. 2020

BMC Complement Med Ther

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Background: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Diosgenin is a natural steroidal saponin with a variety of beneficial effects, including antidiabetic effects, and is a raw material for the synthesis of carrier hormones. In our study, we aimed to assess the antioxidant effects of diosgenin in diabetic mice. Methods: Male C57 mice were fed a high-fat diet for 8 weeks and intraperitoneally injected with streptozotocin (STZ) at a dose of 100 mg/kg for 2 consecutive days. Eligible mice were divided into the normal control group (CON), diabetic group (DM), low-dose diosgenin (50 mg/kg) group (DIO50) and high-dose diosgenin (100 mg/kg) group (DIO100). Treatment was started 6 weeks after the induction of diabetes by STZ and continued for 8 weeks. Blood sugar and body weight were monitored dynamically. The behavioural effects of diosgenin were detected by a hot tail immersion test and paw tactile responses. HE staining was used to evaluate edema and degeneration of the sciatic nerve. The levels of SOD, MDA and GPx were tested according to the instructions of the respective kits. The levels of Nrf2, HO-1 and NQO1 were detected by immunofluorescence and Western blotting. Statistical analysis was performed using SPSS, and P < 0.05 was considered statistically significant. Results: Diosgenin decreased the blood glucose levels and increased the body weight of diabetic mice. There was a significant increase in the tail withdrawal latency of diabetic animals, and mechanical hyperalgesia was significantly alleviated after diosgenin treatment. Histopathological micrographs of HE-stained sciatic nerves showed improvement after diosgenin treatment. Diosgenin attenuated the level of MDA but increased the activities of SOD and GPx. Diosgenin increased the expression of Nrf2, HO-1 and NQO1. Conclusions: Our results demonstrate that diosgenin can ameliorate behavioural and morphological changes in DPN by reducing oxidative stress. The Nrf2/HO-1 signalling pathway was involved in its neuroprotective effects.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

Jin-hong

Tian

et al. 2020

BMC Complement Med Ther

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“…Lycopene is also believed to reduce lipid peroxidation by acting as a good chain-breaking antioxidant, in reacting with peroxyl radicals formed in the propagation phase in the formation of carbon centred radicals. These radicals can react readily and reversibly with oxygen to form new chain-carrying peroxyl radicals, which are highly stable than ROS [28]. Additionally, lycopene was capable to inhibit ROS production induced by 7-ketocholesterol in the human macrophages, directly by its antioxidant properties, or indirectly by its ability in the expression of NADPH oxidase [29].…”

Section: Discussionmentioning

confidence: 99%

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

et al. 2021

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“…25,26 Augmented oxidative stress in turn is a well-known mechanism involved in the development of DPN as evidenced by experimental and clinical studies. [27][28][29] Second, SCH has also been found to be associated with pronounced inflammatory state. [30][31][32][33] The role of proinflammatory state in the pathogenesis of DPN is welldocumented.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

Allam

Nassar

Shabana

et al. 2021

IJGM

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Oxidative stress markers in cognitively intact patients with diabetic neuropathy

Cited by 17 publications

References 31 publications

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

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