The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

Leh, Hui Eng; Sopian, Mastura Mohd; Bakar, Mohamad Hafizi Abu; Lee, Lai Kuan

doi:10.1080/07853890.2021.1943515

Cited by 20 publications

(17 citation statements)

References 28 publications

(28 reference statements)

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“…Similarly, Upritchard et al [ 4 ] supplemented T2DM patients with 500 mL of tomato juice along with Vitamin E and C for 4 weeks, and reported that lycopene supplementation did not affect plasma glucose concentration. Very recently, HbA1c and FPG levels were found to decrease significantly with the higher lycopene intake [ 105 ]. The combined application of cross-sectional, case-control, prospective cohort, and randomized placebo-controlled trials generated a discrepancy in outcomes.…”

Section: Lycopene Consumption and T2dmmentioning

confidence: 99%

Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus

Leh

Lee

2022

Molecules

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Nutrition is of utmost importance in chronic disease management and has often been described as the cornerstone of a variety of non-communicable diseases. In particular, type II diabetes mellitus (T2DM) represents a prevalent and global public health crisis. Lycopene, a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables, has been extensively studied for its biological activities and treatment efficiency in diabetes care. Epidemiological investigations indicate that lycopene has potential antioxidant properties, is capable of scavenging reactive species, and alleviates oxidative stress in T2DM patients. This review aims to summarize the characteristics and mechanisms of action of lycopene as a potent antioxidant for T2DM. In addition, the evidence demonstrating the effects of lycopene on glycemic control and oxidative stress biomarkers in T2DM are also highlighted using animal and human studies as literature approach.

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Section: Lycopene Consumption and T2dmmentioning

confidence: 99%

Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus

Leh

Lee

2022

Molecules

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“…The effects of lycopene administration at 10 and 20 mg lycopene per kg body weight/day for 10 days was examined on the fasting blood glucose, lipids, and glycosylated haemoglobin levels, and a reversal to normality of these parameters was seen with lycopene supplementation [ 273 ]. A recent case-control study reported that lycopene intake positively correlated with peripheral antioxidant activity, antioxidant enzymes superoxide dismutase, and glutathione peroxidase levels and negatively correlated with fasting blood glucose and glycated haemoglobin (HbA1c) levels in patients with type 2 diabetes [ 274 ]. A detailed account of evidence from in vitro, animal, and human studies (cross-sectional, prospective, and two randomised controlled trials) suggesting a preventive role of lycopene and tomato-enriched diet against diabetes is provided by Zhu et al [ 80 ].…”

Section: Health Effectsmentioning

confidence: 99%

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Collins

Bowyer

Tsouza

et al. 2022

Biology

101

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This review outlines the health benefits associated with the regular consumption of tomatoes and tomato products. The first section provides a detailed account of the horticultural techniques that can impact the quality of the fruit and its nutritional properties, including water availability, light intensity, temperature, and growing media. The next section provides information on the components of tomato that are likely to contribute to its health effects. The review then details some of the health benefits associated with tomato consumption, including anticancer properties, cardiovascular and neurodegenerative diseases and skin health. This review also discusses the impact tomatoes can have on the gut microbiome and associated health benefits, including reducing the risk of inflammatory bowel diseases. Other health benefits of eating tomatoes are also discussed in relation to effects on diabetes, the immune response, exercise recovery, and fertility. Finally, this review also addresses the negative effects that can occur as a result of overconsumption of tomato products and lycopene supplements.

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“…Lycopene has been suggested to have clinical efficacy in the treatment of diabetes. The average daily intake of dietary lycopene among diabetics was 0.04 mg/kg BW/d, and lycopene could lower oxidative stress and enhance the pathophysiology of T2DM (Leh et al 2021). Lycopene's anticancer effects on oral cancer (OC) cells reveal that it might activate the PI3K/AKT/m-TOR signaling pathway to suppress EMT and induce apoptosis in OC cells.…”

Section: Clinical Significance Of Lycopenementioning

confidence: 99%

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

et al. 2022

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Lycopene is a group of phytochemicals found in nature, primarily in fruits and vegetables. Lycopene is thought to protect against a variety of diseases attributed to its antioxidant capabilities. Lycopene has anti-inflammatory, anti-cancer, and immunity-boosting qualities, among other biological and pharmacological benefits. COVID-19 (coronavirus disease 19) is an infectious disease caused by the SARS-CoV-2 virus, which has recently emerged as one of the world's leading causes of death. Patients may be asymptomatic or show signs of respiratory, cytokine release syndrome, gastrointestinal, or even multiple organ failure, all of which can lead to death. In COVID-19, inflammation, and cytokine storm are the key pathogenic mechanisms, according to SARS-CoV-2 infection symptoms. ARDS develops in some vulnerable hosts, which is accompanied by an inflammatory "cytokine syndrome" that causes lung damage. Immunological and inflammatory markers were linked to disease severity in mild and severe COVID-19 cases, implying that inflammatory markers, including IL-6, CRP, ESR, and PCT were significantly linked with COVID-19 severity. Patients with severe illness have reduced levels of several immune subsets, including CD4 + T, NK, and CD8 + cells. As a result, lycopene can be commended for bolstering physiological defenses against COVID-19 infections

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The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

Abstract: Lee (2021) The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case-control study,

Cited by 20 publications

References 28 publications

Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus

Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

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