ABSTRAK Stunting merupakan salah satu masalah gizi yang utama pada anak di Indonesia. Stunting menjadi masalah yang serius karena dikaitkan dengan kualitas sumberdaya manusia di kemudian hari. Anak dengan BBLR(Berat Badan Lahir Rendah) beresiko lebih tinggi menjadi stunting. Tujuan untuk mengetahui hubungan antara IMD (Inisiasi Menyusu Dini), dan BBLR dengan stunting pada anak usia 12-24 bulan dengan berat badan lahir rendah. Jenis penelitian adalah observasional analitik dengan menggunakan desain penelitian cross-sectional. Subjek penelitian ditentukan dengan purposive sampling. Subjek terdiri dari 82 balita yang berusia 12-24 bulan dengan BBLR di 2 kecamatan di Kota Surakarta. Pengumpulan data dilakukan dengan wawancara langsung dan pengukuran antropometri. Uji statistik Chi-square digunakan untuk menganalisis hubungan antara variabel IMD dengan stunting dan uji Anova digunakan untuk menganalisis hubungan antara variabel BBLR dengan stunting. Hasil: IMD tidak berhubungan signifikan dengan kejadian stunting (X² = 0,286, p = 0,593), berat badan lahir rendah (BBLR) berhubungan signifikan dengan kejadian stunting pada α 10 % ( F = 1,561, p = 0,087). Kesimpulan: ada hubungan antara Berat Badan Lahir Rendah dengan Kejadian Stunting. Kata kunci: Stunting, IMD, BBLR ABSTRACT Stunting is one of the main nutritional problems in children in Indonesia. Stunting becomes a serious problem because it is associated with the quality of human resources in the future. Children with LBW (Low Birth Weight) are at higher risk of becoming stunting. Objective: To know the relationship between IMD, and LBW with stunting in children aged 12-24 months with low birth weight. The type of research is observational analytic by using cross-sectional research design. Research subject is determined by purposive sampling. Subject consisted of 82 children aged 12-24 months with LBW in 2 districts in Surakarta. Data collection is done by direct interview and anthropometry measurement. Chi-square statistical test is used to analyze the relationship between IMD variable with stunting and Anova test is used to analyze the relationship between LBW variable with stunting. The result: IMD was not significantly associated with stunting incidence (X² = 0.286, p = 0,593), low birth weight (LBW) was significantly associated with stunting incidence at α 10% (F = 1.561, p = 0.087). Conclusion: there is a relationship between Low Birth Weight with Stunting Event. Keywords: Stunting, IMD, BBLR
Background: Endodontic treatment on dental caries with dental granuloma on the periapical has the potential to flare. The symptoms of acute flare in dental granuloma are strongly related to the activation of macrophages that produce pro-inflammatory cytokine through nuclear factor kappa B (NFκB). However, the role of NFκB in dental granuloma has not been widely explained. Purpose: To compare NFκB expression in dental granuloma and dental nongranuloma in the periapical of dental caries. Methods: The periapical lesion of dental granuloma and dental nongranuloma was obtained from patients with dental caries who were subjected to tooth extraction. The periapical lesion was confirmed by periapical radiography and then differentiated by histological and immunohistochemistry by analyzing the NFκB expression. Results: Most dental granulomas were found in females (66.67%) between the ages 36 and 45 (61.11%). Dental granuloma showed higher NFκB expression compared to dental nongranuloma lesions in tooth caries (p=0.021). Conclusion: The dental granuloma tissue of dental caries showed an increase in NFκB expression. Understanding the role of NFκB might provide additional insights into the process of periapical lesion development.
Background: Dental caries with necrotic pulp is a multifactorial disease that attacks enamel involving tooth pulp. The anaerobic bacteria infection in the pulp chamber could induce the formation of periapical granuloma. However, the presence of the most frequently anaerobic bacteria identified in apical periodontitis, Porphyromonas gingivalis and Prevotella intermedia, in periapical granuloma have not been confirmed. Purpose: The aims of study were to determine the presence of Porphyromonas gingivalis and Prevotella intermedia in dental caries with necrotic pulp and to determine its relation to periapical granuloma. Methods: Thirty-six patients of dental caries with necrotic pulp in Dr. Moewardi General Hospital in Surakarta, Indonesia were involved and classified into two groups, the group of patients with periapical granuloma and the group of patients without periapical granuloma. The caries tooth was extracted, and the chronic periapical tissue was swabbed and cultured on blood agar medium in anaerobic condition. The bacterial DNA was extracted from the positive cultures and subjected for Polymerase Chain Reaction (PCR). Results: Periapical granuloma was more likely found in women (
Background: Cancer is caused by uncontrolled cell growth and angiogenesis as a vital component in tumor growth and metastasis. Angiogenesis provides nutrients needed by cancer cells in order to grow. Angiogenesis is triggered by pro-angiogenic mediators and overexpression of these mediators have been associated with malignant phenotype of ovarian cancer. It is thought that the more advanced tumors have higher tumor cell survival, proliferation, invasion, and angiogenesis, so that it will show higher expression of pro-angiogenesis mediators.Objective: To examine the differences in nerve growth factor (NGF), tyrosin kinase receptor A (TrkA), and vascular endothelial growth factor (VEGF) expression level in different stages of epithelial ovarian cancer.Patients and methods: This is a retrospective cross-sectional study conducted from June to August 2019 in the Department of Obstetrics and Gynecology in association with the Department of Anatomic Pathology of Dr. Moewardi General Hospital, Surakarta, Indonesia. The staging of the epithelial ovarian cancer was determined using the FIGO 2014 staging system. NGF, TrkA, and VEGF expression level were determined using immunohistochemical examination.Results:The samples were 53 formalin-fixed, paraffin-embedded ovary, its adnexa, uterus, and lymph nodes tissue blocks of epithelial ovarian cancer patients. There are statistically significant differences in the proportion of NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer (p<0.05).Conclusion: There are statistically significant differences in NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer.
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