Early diagnosis of osteoporosis is important to take early prevention and treatment. Dual energy X-ray absorbtiometry (DEXA) scan is gold standard diagnosis of osteoporosis. However, it is high technology and high cost. Biochemical marker using calcium could be developed for diagnosis of osteoporosis. The study was conducted to evaluate the correlation between serum calcium ions level as well as urine calcium and urine creatinine (UCa/UCr) ratio and Bone Mineral Density (BMD) in perimenopausal and postmenopausal women. This was an observational study with cross-sectional design involving women aged 45-75 years who fulfilled the inclusion and exclusion criteria. Bone Mineral Density was measured using DEXA method. Serum and urine calcium ions were measured using ISE method, while serum and urine creatinine were determined using Jaffe method. Ratio of UCa/UCr were then calculated. The correlation between serum calcium ions as well as the ratio UCa/UCr and BMD of subjects were then analyzed. A total 63 subjects were involved in this study consists of 21 normal subjects, 22 subjects with osteopenia and 20 subjects with osteoporosis. Negative correlation between BMD and age (r=-0.591; p=0.001) and positive correlation between BMD and body mass index (BMI) (r=0.432; p=0.001) were observed. No correlation between serum calcium ions and BMD (r= -0.145; p=0.258), however negative correlation between UCa/UCr ratio and BMD (r=-0.310; p=0.013) were reported. Furthermore, no correlation was found between serum calcium ions and lumbar BMD (r=0.036; p=0.778), while negative correlation was found between UCa/UCr ratio and lumbar BMD (r= -0.414; p=0.001). In conclusion, there is no correlation between serum calcium ions levels and BMD, however there is a weak negative correlation between UCa/UCr ratio and BMD. ABSTRAKDiagnosis dini osteoporosis penting untuk melakukan tindakan pencegahan dan pengobatan sedini mungkin. Skaning Dual-energy X-ray absorbtiometry (DEXA) merupakan diagnosis standar emar osteoporosis. Namun demikian , metode ini perlu teknologi tinggi dan biaya mahal. Marker biokimia kalsium kemungkinan dapat dikembangkan untuk diagnosis osteoporosis. Penelitian ini dilakukan untuk mengkaji hubungan antara kadar ion kalsium serum dan juga rasio kalsium urin/ kreatinin urin (UCa/UCr) dan Densitas Mineral Tulang (Bone Mineral Density/BMD) pada wanita perimenopause dan post menopause. Penelitian ini merupakan penelitian observational dengan rancangan potong lintang yang melibatkan wanita berumur 45-75 tahun yang memenuhi kriteria inklusi dan eksklusi. Ion kalsium urin dan serum ditetapkan dengan metode ISE, sedangkan kreatinin serum dan urin dengan metode Jaffe untuk menghitung rasio UCa/UCr. Hubungan antara ion kalsium serum dan juga juga rasio UCa/UCr dengan BMD selanjutnya dievaluasi. Dari total 63 subjek yang terlibat terdiri dari 21 subjek normal, 22 subjek mengalami osteopenia dan 20 subjek mengalami osteoporosis. Terdapat hubungan negatif BMD dan umur 591; 62 J Med Sci, Volume 46,No. 2, p=0,001) dan hub...
Regarding to the ageing population in most countries, degenerative and metabolism diseases included osteoporosis are becoming increasingly and need special attention in all country especially in the developing country such as Indonesia. Current WHO recommendation of using a gold standard for establishing osteoporosis is by Dual X-Ray Absorptiometry (DEXA), but it is expensive and not yet widely available. There are some alternatives of biochemical markers that can reflect the bone turn over. One of them is Cterminal cross-linking telopeptide of type I collagen (CTX) or betacrosslabs, a marker of bone resorbtion. There are still limited studies on correlation of CTX and osteoporosis in peri menopausal and post menopausal women. The aim of this study is to know whether there are any differences of CTX level among peri menopausal and post menopausal women with different bone density. This research was a cross sectional study and aimed to know whether there is any correlation between CTX level and Bone Mineral Density Score measured with DEXA. The study was conducted in June-August 2010. The included subjects were women with age more than 45 years old, without apparent history of neoplasm, impaired renal function, bone metabolic diseases, and not currently pregnant. CTX level were measured using immunochemiluminescent. Their data were analysed using One Way ANOVA. This study showed that there are differences of CTX levels among women with osteoporosis, osteopenia, and normal (0.633±0.25 ng/mL vs 0.514±0.21 ng/mL vs 0.406±0.21 ng/mL p=0.02). Osteoporosis women have higher CTX level compared to Osteopenia and Normal women.
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