Management of patients irradiated for oral cancer should include consideration of their oral health prior to, and after, radiation therapy. Data from 130 patients, followed for a period of 1 to 10 years, are presented and evaluated. The philosophy of retention and maintenance of as many teeth as possible is supported by this data. Extraction of teeth with severe periodontal disease after irradiation also proves to be a relatively safe operation. Osteoradionecrosis tends to be limited in extent and is generally well tolerated by the patient when treated conservatively. A treatment regimen is presented that significantly reduces the morbidity from therapeutic irradiation of the jaws. A comprehensive dental evaluation and follow-up plan coupled with patient cooperation are instrumental to the success of this program.

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Regezi JA, Zarbo RJ, Tomich CE, Lloyd RV, Courtney RM, Crissman JD. Immunoprofile of benign and malignant fibrohistioeytic tumors. J Oral Pathol 1987: 16: 260-265.Formalin-fixed, paraffin-embedded tissue seetions from 26 malignant fibrous histioeytomas (MFH) and 61 benign fibrohistiocytic proliferations (BFHP) were evaluated immunohistochemieally. An avidinbiotin-peroxidase technique was used to determine immunoreactivity for alpha-1 antiehymotrypsin, muramidase, HLA-DR, leueocyte common antigen, S-100 protein, vimentin, desmin, and keratin. MFHs were eonsistently positive for ACT and vimentin and inconsistently reactive for the other antigens. MFHs were negative for LCA suggesting a mesenehymal origin for these lesions. In the MFH histoiogie subtypes, antigen expression was not signifieantly different to be useful in their classification. Also no distinctive pattern emerged relative to immunoreactivity and tumor location. The benign lesions, giant eell tumor of tendon sheath, dermatofibroma, and oral benign fibrous histiocytoma differed from the MFHs in that they were often LCA positive, suggesting origin from hematopoetie mononuclear-maerophages. The immunoprofiles of peripheral fibromas and "giant cell" fibromas were felt to be consistent with origin from mesenchymal eells. Several of the antigens studied eould be used to differentiate the benign lesions studied from other benign neoplasms. The antigens were, however, of little value in separation of benign and malignant lesions.

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