“…Concerning local pathological conditions, marginal periodontitis (Niewald et al, 1996, Jereczek-Fossa and Orecchia, 2002, Katsura et al, 2008, Oh et al, 2009) and denture irritation (Thorn et al, 2000, Oh et al, 2009 have been implicated in the development of ORN. The reason is that an open wound is present in the oral cavity during and after RT in these cases (Regezi et al, 1976, Murray et al, 1980a, 1980c, Beumer et al, 1984, Kluth et al, 1988, Bachmann et al, 1996, Katsura et al, 2008.…”