Keratinization in odontogenic tumors

Regezi, Joseph A.; Courtney, Richard M.; Kerr, Donald A.

doi:10.1016/0030-4220(75)90088-2

Cited by 53 publications

(29 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although their nature is still unclear, the majority of authors consider these cells a form of true or aberrant keratinization, but the true nature of these cells has not been determined [30,31]. They are characteristically observed in calcifying cystic odontogenic tumors, in ameloblastoma, in ameloblastic fibroodontoma, and in odontoma [32,33]. In this case, the fluorescence may be ascribed to keratin presence, in agreement with a number of studies reporting high autofluorescence intensity of keratin [18,34].…”

Section: Discussionsupporting

confidence: 79%

Calcifying Odontogenic Cysts Associated with Odontomas: Confocal Laser Scanning Microscopy Analysis of 13 Cases

Lucchese

Petruzzi

Scivetti

et al. 2011

Ultrastructural Pathology

View full text Add to dashboard Cite

The so-called calcifying odontogenic cyst (COC) represents a heterogeneous group of lesions that exhibit a variety of clinico-pathologic features. It is an uncommon lesion and represents less than 2% of all odontogenic cysts and tumors. Recently, these lesions have been reclassified as calcifying cystic odontogenic tumors (CCOT), according to the new World Health Organization (WHO) classification. CCOT are frequently found in association with, or containing areas histologically identical to, various types of odontogenic tumors, such as complex/compound odontomas. This work analyzed clinical and histological data deriving from 13 patients affected by CCOT associated with odontomas. Moreover, a confocal laser scanning microscope (CLSM) analysis was undertaken to further a better understanding of the nature of this peculiar lesion.

show abstract

Section: Discussionsupporting

confidence: 79%

Calcifying Odontogenic Cysts Associated with Odontomas: Confocal Laser Scanning Microscopy Analysis of 13 Cases

Lucchese

Petruzzi

Scivetti

et al. 2011

Ultrastructural Pathology

View full text Add to dashboard Cite

show abstract

“…Even in a peripheral ameloblastoma, small areas of ghost cells are evident (our unpublished case). Conceivably, they are neither unique to nor pathognomonic of OGCT (61). The second distinguishing feature is dentinoid induction, but dentinoid may be present in conventional ameloblastoma-dentinoameloblastoma as described within the later section in this treatise.…”

Section: Hybrid Tumor Of Ameloblastoma and Calcifying Odontogenic Cystmentioning

confidence: 99%

“…Thus, several authors consider OGCTs to be variants of ameloblastoma. They recommended the term keratinizing ameloblastoma (60,61), dentinogenic ghost-cell ameloblastoma (56), ameloblastoma ex COC (57) or ghost cell ameloblastoma (59).…”

Section: Hybrid Tumor Of Ameloblastoma and Calcifying Odontogenic Cystmentioning

confidence: 99%

So-called Hybrid Odontogenic Tumors: Do they really exist?

et al. 2001

View full text Add to dashboard Cite

“…In an immunohistochemical analysis, Piattelli and Trisi (35) demonstrated that ghost cells were negative for normal keratin. Furthermore, scanning electron microscopy studies have shown that the pattern formed by large tonofilament bundles in ghost cells is unlike that normally found in orthokeratinized or parakeratinized epithelium, and since the production of keratin is not a natural function of odontogenic epithelium, the ultrastructural features of ghost cell keratinization should be interpreted as indicating the production of an aberrant or unusual form of keratin, and not true keratin (29)(30)(31). However, CCOTs, including adamantinomatous-type CP and PM, express hard α-keratin in ghost cells and shadow cells (28).…”

Section: Discussionmentioning

confidence: 99%

“…Other odontogenic tumors in which ghost cells appear as a secondary phenomenon include odontoma (29)(30)(31)(32)(33)(34)(35). With regard to the origin of ghost cells, it is thought that odontogenic epithelium undergoes metaplastic transformation with keratinization (32,33,35).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of podoplanin in so-called hard ^|^alpha;-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma

et al. 2012

View full text Add to dashboard Cite

Podoplanin, a transmembrane sialomucin-like glycoprotein, is a specific marker of lymphatic vessels, and its expression is also considered to be associated with tumor invasion and tooth development. In this study, we examined the expression of podoplanin in calcifying cystic odontogenic tumor (CCOT) in comparison with that in other so-called hard α-keratin-expressing tumors such as craniopharyngioma (CP) and pilomatrixoma (PM). Immunohistochemical staining for podoplanin was carried out using surgical specimens of 15 CCOTs of the jaw, 19 CPs of the pituitary gland, and 15 PMs of the skin. Positivity for hard α-keratin was evident in ghost, shadow and transitional cells in all of these tumors (100%). The podoplanin expression in CCOTs was evident in the periphery of ameloblastoma-like epithelium (86.6%) and the epithelial cells adjacent to ghost cells (60%). On the other hand, in adamantinomatous-type CPs, podoplanin expression was observed in epithelial components corresponding to the stratum intermedium (100%), but not in the periphery of ameloblastoma-like epithelium (0%). In squamoustype CPs podoplanin was expressed in basal cells (100%), but all of the PMs were podoplanin-negative (0%). In the periphery of the ameloblastoma-like epithelium or basophilic cell layer, podoplanin was expressed more strongly in CCOTs than in CPs or PMs. These findings suggest that the expression of podoplanin in CCOTs may reflect rapid turnover of cytoskeletal filaments and local invasiveness. (J Oral Sci 54, [165][166][167][168][169][170][171][172][173][174][175] 2012)

show abstract

Keratinization in odontogenic tumors

Cited by 53 publications

References 6 publications

Calcifying Odontogenic Cysts Associated with Odontomas: Confocal Laser Scanning Microscopy Analysis of 13 Cases

Calcifying Odontogenic Cysts Associated with Odontomas: Confocal Laser Scanning Microscopy Analysis of 13 Cases

So-called Hybrid Odontogenic Tumors: Do they really exist?

Immunohistochemical expression of podoplanin in so-called hard ^|^alpha;-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma

Contact Info

Product

Resources

About