So-called Hybrid Odontogenic Tumors: Do they really exist?

A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma

“…These ambiguous tumors should not generally be considered true hybrids; rather they should be identified simply as anomalous histodifferentiation and/or morphodifferentiation process. [ 3 ] To call them as hybrid tumors would be a misnomer. Melrose wrote that the designation hybrid tumor serves no real purpose.…”

“…[ 1 ] Despite the World Health Organization (WHO) classification of odontogenic tumors, unique odontogenic lesions with combined histologic features have been encountered occasionally. [ 2 ] Hybrid tumors are very rare tumor entities, which are composed of two different tumor entities, each of which confirms with an exactly defined tumor category whereas a hybrid odontogenic tumor is defined as follows: “A lesion showing the combined histopathological characteristics of two or more previously recognized tumors and/or cysts of different categories.”[ 3 ] Ameloblastoma is a benign odontogenic tumor arising from the odontogenic apparatus showing odontogenic epithelium with mature fibrous stroma, without ectomesenchyme. It is the best known and the most frequently seen odontogenic tumor.…”

Hybrid Odontogenic Tumors: A Controversy

“…The term Hybrid tumor was first used for salivary gland tumors [2]. A hybrid tumor of odontogenic apparatus is a lesion showing combined histopathological characteristics of two or more previously recognized odontogenic tumors and\ or cysts of different categories [3]. Unlike collision tumor, tumor entities in a hybrid tumor are not separated but have an identical origin within the same topographical area.…”

An Aggressive Lesion of Anterior Maxilla

“…2,3,17 In the reported case blood-mixed aspiratory fluid was obtained. Nigam 18,19 In the adenomatoid odontogenic tumor, hard tissues may occur as dysplastic dentin, enamel matrix and dystrophic calcifications. 1 In the reported case, there was dystrophic calcification along with dentinoid formation was observed.…”