Hybrid Odontogenic Tumors: A Controversy

Hybrid odontogenic tumor masquerading as a salivary gland lesion: A diagnostic predicament

“…[ 4 ] Hybrid odontogenic tumors comprise of histopathological characteristics of two or more previously recognized odontogenic tumors and or cysts of different categories. [ 5 ] They must be differentiated from “collision tumors” in which two tumors of different histogenetic source or different topographical area develop simultaneously and then meet in the border zone. The exact etiology of hybrid odontogenic tumors is hitherto unknown; however, it is stipulated that the pluripotent odontogenic epithelium can give rise to divergent histological patterns within the same tumor.…”

“…The exact etiology of hybrid odontogenic tumors is hitherto unknown; however, it is stipulated that the pluripotent odontogenic epithelium can give rise to divergent histological patterns within the same tumor. [ 5 ] The CEOT or Pindborg tumor is another commonly occurring tumor composed principally of polyhedral epithelial cells with homogeneous eosinophilic material probably amyloid. [ 6 ] In addition, calcification is a regular phenomenon in this group of lesion, and the same was evident in the present case.…”

A case report of synchronous ameloblastoma and odontogenic keratocyst of the mandible

“…The current case is considered synchronous due to the simultaneous occurrence of two separate entities within the mandible. In contrast, hybrid odontogenic tumours are lesions showing concurrent histopathological features of two or more odontogenic tumours or cysts 24 . One helpful difference distinguishing between synchronous and hybrid lesions is the location of the lesions, with hybrid lesions always being ipsilateral, and synchronous either ipsilateral or contralateral.…”

Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma

“…The term “hybrid lesions” was first introduced by Waldron and El-Mofty during their work on cases of ameloblastoma 17 . Later, it was generally accepted that “hybrid” lesions represent those lesions that comprise significant portions of histopathological features of multiple, completely different entities 18– 20 . We believe that this reported case represents a hybrid lesion.…”