Fibrous lesions of the skin and mucous membranes which contain stellate and multinucleated cells

Regezi, Joseph A.; Courtney, Richard M.; Kerr, Donald A.

doi:10.1016/0030-4220(75)90202-9

Cited by 37 publications

(30 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The profile with positive staining for vimentin is in agreement with the result of Regezi et al (8). These results indicate that the stellate cells are of fibroblastic origin.…”

Section: Discussionsupporting

confidence: 93%

The giant cell fibroma A review of 103 cases with immunohistochemical findings

Magnusson

Rasmusson

1995

Acta Odontologica Scandinavica

View full text Add to dashboard Cite

This article reports a series of 103 cases of giant cell fibromas occurring in the oral mucosa. The commonest location was the gingiva, followed by the tongue and the buccal mucosa. The mean age of the patients was 27.7 years, and the median age 21 years. Microscopically, the tumors were characterized by the presence of large stellate or angular cells, which occasionally contained several nuclei. Immunohistochemical stains showed that the cells were vimentin-positive but negative for S-100 protein, cytokeratin, leukocyte common antigen, and neurofilament.

show abstract

“…The profile with positive staining for vimentin is in agreement with the result of Regezi et al (8). These results indicate that the stellate cells are of fibroblastic origin.…”

Section: Discussionsupporting

confidence: 93%

The giant cell fibroma A review of 103 cases with immunohistochemical findings

Magnusson

Rasmusson

1995

Acta Odontologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…In favor ofthe above-mentioned hypothesis regarding the function of the stellate and multinucleated cells, ultrastructural studies presented evidence of protein synthesis in the characteristic cells based on the presence of abundant rough endoplasmic reticulum (16,22). Furthermore, numerous microfibrils were found in the cells (22).…”

Section: Discussionmentioning

confidence: 84%

“…Furthermore, cells with a similar morphology are reported in the fibrous tissue covering impacted permanent second premolars (13), in various cutaneous tumors, hamartomas, or reactive hyperplasias (8,12,14,15,18,20), and in lesions on glans penis (1). Thus it seems reasonable to hypothesize that the characteristic cells are part of a nonspecific reaction in fibrous hyperplasias as suggested by REGEZI et al (16).…”

Section: Discussionmentioning

confidence: 93%

Oral fibrous hyperplasias containing stellate and multinucleated cells

Reibel

1982

European J Oral Sciences

View full text Add to dashboard Cite

Reibel, J.: Oral fibroos hyperplasias containing stellate and multinucleated cells. Scand. J. Dent. Res. 1982: 90: 217-226. Abstract -In an attempt to clarify whether the so-called "giant-cell fibroma" is a separate entity among fibrous hyperplasias and tumors, 1550 oral fibroas hyperplasias were reviewed for the presence of stellate and multinucleated cells. In 5% ofthe lesions stellate and multinucleated cells Wicre a dominant feature of the histologic picture. A surprisingly high number of hyperpiasias of the tuberosities {gingivai fibromatoses) were found to contain the characteristic cells. (31 %). On the basis, ofthe varying nature of the lesions and the range of ages at which the stellate and multinucleated cells are found, these lesions should not be regarded as neoplastic in nature or as belonging to a separate en tit)'. Furthermore, based on differences in fiber pattern and iocalizadon ofthe characteristic cells, it is suggested that the stellate and multinydeated cells are active cells, possibly involved in the synthesis of eoUagen and/or ground substance.

show abstract

“…GCF is characterized by the presence of numerous large stellate and multinucleated giant cells in a loose collagenous stroma. These pathognomonic cells are never hyperchromatic, as they would be if they were truly dysplastic fibroblasts, and they often have a smudged appearance (2,17). Ultrastructural examination has suggested that the stellate and multinucleated giant cells are unusual fibroblasts (2,18,19).…”

Section: Discussionmentioning

confidence: 99%

A Case Report and Update of Giant Cell Fibroma

Madi¹,

Shetty²,

Babu³

et al. 2014

MUSBED

View full text Add to dashboard Cite

ÖZET Dev hücreli fibroma ile ilgili olgu raporu ve güncellemeDev hücreli fibroma, geleneksel fibromdan ayırt edici klinikopatolojik özelliklerle ayrılan fibröz bir tümördür. Biyopsi alınan tüm oral fibröz proliferasyonların yaklaşık %2 ile %5'ini oluşturmakla beraber ağırlıklı olarak Kafkaslarda nadiren diğer ırklarda görü-lür. Çoğu zaman dev hücreli fibroma, papiller yüzeyi nedeniyle papilloma ile ya da fibröz veya elastik yapısından dolayı fibrom ile karıştırılmaktadır. Bu olgu sunumunda 30 yaşındaki otistik bir kadın hastanın kesici papilla bölgesinde gözlenen dev hücreli fibroma anlatılmaktadır. Anahtar sözcükler: Dev hücreli fibroma, fibrom, histopatoloji, dev hücreler ABS TRACTA case report and update of giant cell fibromaThe giant cell fibroma is a fibrous tumour with a distinctive clinicopathologic features which sets it apart from a conventional fibroma. It represents approximately 2% to 5% of all oral fibrous proliferations submitted for biopsy and is found predominantly in Caucasians and rarely in other races. Most often giant cell fibroma is mistaken for papilloma because of its papillary surface or fibroma because of its fibrous or elastic nature. Here, we report a case of giant cell fibroma, in the region of the incisive papilla, in a 30-year old autistic female.

show abstract

Fibrous lesions of the skin and mucous membranes which contain stellate and multinucleated cells

Cited by 37 publications

References 8 publications

The giant cell fibroma A review of 103 cases with immunohistochemical findings

The giant cell fibroma A review of 103 cases with immunohistochemical findings

Oral fibrous hyperplasias containing stellate and multinucleated cells

A Case Report and Update of Giant Cell Fibroma

Contact Info

Product

Resources

About