Nanomedicine are a relatively new but quickly expanding discipline in which tiny materials are used as diagnostic instruments or to administer therapeutic drugs to particular targets in a controlled manner. Nanotechnology provides a number of advantages in the treatment of chronic human diseases by allowing precise medications to be delivered to particular locations. There have been several notable uses of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, etc.) in the treatment of various illnesses in recent years. Neverthless, In current scenario there are phytochemicals are also present whom are responsible for prevention of devastating diseases. In this review it has been highlighted that there are real possible outcomes present, in the case of the combined treatment strategies of phytochemicals and nanoparticles. Eventually, this combined drug delivery system play crucial role in anti-cancer, anti-alzehimar, anti-bacterial and many more complicated maladies. We also focused on the preclinical and clinical study regarding the drug delivery system. Here, the types of phytochemicals along with their bioavilability also mentioned. Additionally, the Nanomedicines' advantages and disadvantages in drug delivery from synthetic to natural sources to clinical applications are also explored. In addition, we've added information about nanomedicine's developments by attaching with phytochemicals with respect to the diseases and future prospects.
Nanotechnology manifests the progression within stage of research and development, by increasing the efficacy of the merchandise through delivery of innovative solutions. to beat certain drawbacks associated with the traditional products, application of nanotechnology is escalating within the world of cosmeceuticals. In private care industry, cosmeceuticals are considered the fastest growing segment and thus the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have inherit widespread use. Novel nanocarriers like nano emulsions, liposomes, microemulsions, niosomes, solid lipid nanoparticles, nanospheres and nanostructured lipid carrier have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of controlled and sustained drug release, enhanced skin penetration, higher stability, high entrapment efficiency and site-specific targeting. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology utilized in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, marketed formulations, their positive and negative aspects, toxicity, and regulations of nanocosmeceuticals.
Viral diseases continue to be a public threat on a global scale day by day and the world is in a continuing battle with the novel deadly viral Diseases and with no prompt medicines accessible the scourge brought about by the disease is expanding step by step. The ongoing need to develop new antiviral drugs with fewer side-effects and that are effective against viral pathogens has spurred the research community to invest in various drug discovery strategies, one of which is drug repurposing the methods of finding most promising existing compounds which has able to give best positive effects against viral infections. We present a docking?based screening using a quantum mechanical scoring of drug Curcumin with Proteins with PDB id’s 4B3V, 5LK0, 6BM8, 4QUZ, 6SJV, 1JLF, 5EG7, 7K40 could display antiviral activity against Rubella, Hanta, Herpes, Noro, papilloma, HIV, Influenza, COVID19. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the viral disease. We hope that repurposing of the drug from our recommendation may contribute to the rational drug design against the above viruses.
Nanoparticles (NPs) a potential next generation candidate for human well-being in the world of healthcare, have been observed to be effective anti-bacterial agents. The significance of nanoparticles as anti-bacterial agents has taken spotlight, due to the inability of pathogenic bacteria to develop resistance against NPs. In this review, mode of action of some scientifically important anti-bacterial NPs were discussed, along with summary of recent pre-clinical and clinical studies reported on anti-bacterial NPs are discussed. Some of the current hurdles and barriers that should be addressed to complete marketability and human applications, in regards to NPs as nanomedicines are also critically discussed along with focus on reported toxicity in NPs. Some additional pharmaceutical effects of NPs, reported in the recent years, such as antidiabetic and anticancer are also included for discussion. This review provides significant information on recent discoveries in the field of nanomedicines as antibiotics, that show promising future for drug development and drug delivery. As in every human domain, evidence begins to point to the actual undeniable fact that in conjunction with the existing medicine, nanomedicines could be the future of the healthcare that replace or enhance the potential current pharmaceutical drugs.
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