Nanoparticle’s Significance as Antibacterial Agents & Other Pharmaceutical Applications and Their Limitations: A Critical Review

Abstract

Nanoparticles (NPs) a potential next generation candidate for human well-being in the world of healthcare, have been observed to be effective anti-bacterial agents. The significance of nanoparticles as anti-bacterial agents has taken spotlight, due to the inability of pathogenic bacteria to develop resistance against NPs. In this review, mode of action of some scientifically important anti-bacterial NPs were discussed, along with summary of recent pre-clinical and clinical studies reported on anti-bacterial NPs are discussed. Some of the current hurdles and barriers that should be addressed to complete marketability and human applications, in regards to NPs as nanomedicines are also critically discussed along with focus on reported toxicity in NPs. Some additional pharmaceutical effects of NPs, reported in the recent years, such as antidiabetic and anticancer are also included for discussion. This review provides significant information on recent discoveries in the field of nanomedicines as antibiotics, that show promising future for drug development and drug delivery. As in every human domain, evidence begins to point to the actual undeniable fact that in conjunction with the existing medicine, nanomedicines could be the future of the healthcare that replace or enhance the potential current pharmaceutical drugs.

High-Throughput Screening and Dynamic Studies of Selected Compounds Against Sars-Cov-2

“…Currently, scientists and researchers are attempting to identify potential drug targets and related mechanistic aspects that can aid in the development of novel therapeutics for this infectious virus; several preclinical studies have suggested various FDA-approved drugs for clinical trials, and importantly, the administration of these drugs can be associated with severe adverse side effects due to Innovative targeted drug delivery systems (multifunctionalization for specific tissue/organ targeting), nano-based structures, metal-grafted graphene oxide, nanocomposites, nano-phytotherapeutics, biodegradable nanocarriers, carbon nanotubes, and multidrug nanoparticles can all contribute to the fight against the SARS-CoV-2 virus. The aim of this current study was to generate suitable drug candidates from previously used nanoparticles as well as nanocarrier drug delivery systems to counter the 3CLpro protein of SARS CoV-2 with the help of virtual screening and molecular docking techniques [18,19].…”