Modern Developments of Nano Based Drug Delivery System by Combined with Phytochemicals- Presenting New Aspects

Abstract

Nanomedicine are a relatively new but quickly expanding discipline in which tiny materials are used as diagnostic instruments or to administer therapeutic drugs to particular targets in a controlled manner. Nanotechnology provides a number of advantages in the treatment of chronic human diseases by allowing precise medications to be delivered to particular locations. There have been several notable uses of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, etc.) in the treatment of various illnesses in recent years. Neverthless, In current scenario there are phytochemicals are also present whom are responsible for prevention of devastating diseases. In this review it has been highlighted that there are real possible outcomes present, in the case of the combined treatment strategies of phytochemicals and nanoparticles. Eventually, this combined drug delivery system play crucial role in anti-cancer, anti-alzehimar, anti-bacterial and many more complicated maladies. We also focused on the preclinical and clinical study regarding the drug delivery system. Here, the types of phytochemicals along with their bioavilability also mentioned. Additionally, the Nanomedicines' advantages and disadvantages in drug delivery from synthetic to natural sources to clinical applications are also explored. In addition, we've added information about nanomedicine's developments by attaching with phytochemicals with respect to the diseases and future prospects.

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

“…The breakdown of the BBB is an important step in the development of therapies for central nervous system (CNS) syndromes. In this situation, the intranasal route of drug administration has also been projected as a non-invasive alternate route for straight targeting of the CNS [ 106 ]. This method of drug administration avoids the BBB, reducing systemic toxicity.…”

Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles

“…Owing to their size, many phytoconstituents have limited adsorption capacity and implicitly low bioavailability, which represents one of the main issues associated with drug discovery based on natural compounds. Another concern is attributed to the variation in metabolic composition depending on various biotic and abiotic parameters, as well as the highly complex chemical structure with numerous chiral centers [ 11 , 12 ]. However, the current trend in traditional medicine offers the advantage of using natural products, eliminating the multiple side effects of synthetic drugs.…”

“…However, the current trend in traditional medicine offers the advantage of using natural products, eliminating the multiple side effects of synthetic drugs. Consequently, recent studies have focused on the design of innovative materials based on natural products, with increased pharmacological efficiency, controlled release, specific site targeting and extended action [ 11 , 12 ]. In this sense, special attention had been paid to phytoconstituents with neuroprotective, antitumor, antioxidant and anti-inflammatory activity [ 11 ].…”

“…Therefore, various types of nanoparticles have been investigated for biomedical applications, such as silver, gold, iron oxide and silica. However, gold and silver nanoparticles stand out, proving superior owing to their high biocompatibility and versatility [ 11 , 12 ]. Medical applications of silver have been known since ancient times [ 13 ].…”

“…Hence, the latest nanodelivery systems are the result of the association of natural products with nanoparticles (by encapsulating or attaching biomolecules) with very high biological activity and minimal toxicity. Studies have reported that these nanostructures can mitigate the effects of drug resistance, opening up new therapeutic possibilities [ 11 , 12 , 19 , 20 ].…”