Several 6-substituted-3-[(5-mercepto-1,3,4-oxadiazol-2-yl)methyl]-2-substituted quinazolin-4(3H)-one or 6-substituted-3-[4-(5-mercepto-1,3,4-oxadiazol-2-yl)phenyl]-2-substituedquinazolin-4(3H)-one 2(a-l) and 6-substituted-3-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-2-substitutedquinazolin-4(3H)-one or 6-substituted-3-[4-(5-phenyl-1,3,4-oxadiazol-2-yl) phenyl]-2-substitutedquinazolin-4(3H)-one 3(a-l) were synthesized using conventional and microwave techniques respectively and were screened for antibacterial and antifungal activity. Introduction.
A series of sixteen substituted pyrazole oxadiazole derivatives are designed, synthesised and characterized by 1H NMR, 13C NMR and mass spectrometry. The ligands have been docked with Acetylcholine receptor to understand the binding efficiency and amino acids interactions, indicative of all of the sixteen molecules bind efficiently better than Fipronil and Pyrafluprole. These compounds will provide a lead for designing new compounds with improved insecticidal activity.
Several 2-[2-{(4-substitutedbenzylidene)-phenyl}vinyl]-4-oxo-3,4-dihydroquinazolone-6-sulfonicacid 4(a-l) and 2-[2-{4-(3-chloro-4-substituedphenylazetidin-2-one)-phenyl}vinyl]-4-oxo-3,4-dihydroqui-nazolone-6-sulfonic acid 5(a-l) were synthesized by using conventional techniques and were screened for antibacterial and antifungal activity. The compounds showed good to moderate antimicrobial activity and were characterized on the basis of spectral analysis. .
1,3,4-oxadiazole derivatives of type (V) are prepared and screened for their antibacterial and antifungal activities. -(DESAI, A. R.; DESAI*, K. R.; J. Heterocycl. Chem. 42 (2005) 5, 995-999; Dep. Chem., South Gujarat Univ., Surat 395 007, India; Eng.) -M. Bohle 49-143
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