Saliva as a diagnostic biofluid offers a number of advantages over blood-based testing. The role of IL-8 in oral cancer if validated further by future research can provide an easy diagnostic test as well as a prognostic indicator for patients undergoing treatment. Therefore, if it's role in tumourigenesis can be sufficiently assessed, it could open up new avenues to find out novel treatment modalities for oral cancer.
Aim:Transmission of human immunodeficiency virus (HIV) in the oral cavity is a rare event, despite detectable virus in saliva and oropharyngeal tissues of infected persons, unlike other mucosal sites. Secretory leukocyte protease inhibitor (SLPI) has been suggested as the main soluble factor responsible for the HIV inhibitory effect of saliva. The study was designed to estimate and compare the salivary SLPI levels in HIV patients and healthy controls. Furthermore, the relationship between salivary SLPI levels and disease severity was also investigated.Materials and Methods:Unstimulated whole saliva specimens were collected from 60 HIV-infected and 20 healthy subjects. Disease severity was determined by CD4 count in HIV subjects, who were divided into two groups: ≥200 cells/μL (n = 30) and < 200 cells/μL n = 30. Salivary SLPI levels were determined by enzyme-linked immunosorbent assay.Results:Numerically higher SLPI levels were observed in HIV subjects 193.342 ng/mL vs. 190.587 ng/mL; P = 0.517. A nonsignificant negative correlation was noted between CD4 counts and SLPI levels r = −0.037, P = 0.781.Conclusion:The salivary anti-HIV factor, SLPI, is not only preserved in HIV infection but its concentration may even get enhanced in the infection. However, the clinical significance of SLPI levels and disease severity should be investigated further with a larger sample of patients.
Context: Age estimation plays an important role in forensic medicine, paediatric endocrinology, archaeology, and clinical dentistry. Of the various methods which use stages of tooth calcification to predict age, Chaillet-Demirjian's and Willem's methods are most commonly used. But, as variations in dental development exist between different ethnic groups and populations, the foreign dental standards and data might not be applicable to local population. Thus, every method should be tested over the local population to assess its applicability & accuracy, and the necessary modifications should be suggested for its greatest accuracy. Aims: To evaluate the applicability of dental age estimation methods, and if necessitates, to derive a Chhattisgarh population specific formula for the highest accuracy. Settings and Design: Prospective and observational correlation study. Methods and Material: Orthopantomograms of 103 males & 107 females, in age group 7-16 years, from Chhattisgarh population, were taken and evaluated by Chaillet-Demirjian's and Willem's methods for dental age estimation. Statistical analysis used: Paired student's t-test, Pearson's correlation and regression analysis. Results: An underestimation of age by Chaillet-Demirjian's method, and an overestimation of age by Willem's method were observed in Chhattisgarh population. Therefore, the Regression analysis was carried out to develop a formula for Chhattisgarh population for estimation of their accurate age. Conclusions: Though both the methods showed close correlation with the chronological age (CA), there was a remarkable difference from the actual age. Hence, a Chhattisgarh population specific formula for the highest accuracy has been derived and proposed.
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