Salivary level of interleukin-8 in oral precancer and oral squamous cell carcinoma

Punyani, Silky R.; Sathawane, Ramhari

doi:10.1007/s00784-012-0723-3

Cited by 79 publications

(72 citation statements)

References 44 publications

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“…In addition, the levels of TNF-α [21], IL-6 [21,22,31,32], IL-8 [31] and IL-1β [21] are increased in the serum of patients with potentially malignant disorders. In OSCC, the saliva interleukins TNF-α [19,24,30], IL-6 [19-21, 23, 24, 29, 30], IL-8 [20,24,26,28,30], IL-1β [21], IL-1α [24,30] and vascular endothelial growth factor (VEGF) [24] are elevated. Changes in TNF-α [25], IL-6 [22,25,26], IL-1β [21] and VEGF [27] levels in OSCC have also been described.…”

Section: Discussionmentioning

confidence: 99%

“…Cytokines and chemokines have been analysed in patients with OSCC [19][20][21][22][23][24][25][26][27][28][29], and in potentially malignant disorders, most commonly interleukin-6 (IL-6) [19,21,22,[30][31][32][33]. IL-6 is a multifunctional cytokine produced by macrophages, neutrophils, fibroblasts, keratinocytes and endothelial cells [34].…”

Section: Introductionmentioning

confidence: 99%

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Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

et al. 2015

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“…This observation was later confirmed by exploring a larger patient group 70 . The degree of elevation was consistent with OSCC histologic grading 71 , and significant when compared to the precancer, chronic periodontitis, oral lichen planus, and healthy control groups [72][73][74] . In a similar fashion, CXCL8 levels in squamous cell carcinoma of the tongue correlated with increased metastasis and poor prognosis 75 .…”

mentioning

confidence: 73%

Chemokines in tumor proximal fluids

Kotyza¹

2017

BIOMED PAP

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Chemokines are chemotactic cytokines produced by leukocytes and other types of cells including tumor cells. Their action is determined by the expression of cognate receptors and subsequent signaling in target cells, followed by the modulation of cytoskeletal proteins and the induction of other responses. In tumors, chemokines produced by neoplastic/stroma cells control the leukocyte infiltrate influencing tumor growth and progression. Tumor cells also express functional chemokine receptors responding to chemokine signals, promoting cell survival, proliferation and metastasis formation. Chemokines may be detected in serum of cancer patients, but due to the paracrine nature of these molecules, more significant concentrations are found in the tumor adjacent, non-vascular fluids, collectively called tumor proximal fluids. This review summarizes the expression of CC and CXC chemokines in these fluids, namely in interstitial fluid, pleural, ascitic, and cyst fluids, but also in urine, saliva, cerebrospinal fluid, cervical secretions and bronchoalveolar lavage fluid. Most comparative clinical studies reveal increased chemokine levels in high-grade tumor proximal fluids rather than in low-grade tumors and benign conditions, indicating shorter survival periods. The data confirm peritumoral fluid chemokines as sensitive diagnostic and prognostic markers, as well as offer support for chemokines and their receptors as potential targets for antitumor therapy.

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“…(p˂0.0001) But the different between healthy subjects and patients with premalignant lesions was not significant. (p=0.738) (21) In another study by Sahebjamee et al, the concentrations of IL-8, IL6, IL1α and TNFα were compared between OSCC patients and healthy subjects.…”

Section: Discussionmentioning

confidence: 98%

Comparison of the concentration of salivary IL8 in patients with oral squamous cell carcinoma and healthy subjects

Azizi

Dabirmoghadam

Keykha³

2016

J Res Dentomaxillofac Sci

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Background and Aim:Oral cancer is one of the most common cancers of the head and neck. Considering the high prevalence and mortality percentage of oral cancer and the significant advances in immunology and identification of different cytokines, the aim of the present study was to compare the concentration of IL8 in saliva of patients with oral squamous cell carcinoma (OSCC) and healthy subjects. Methods and Materials:In this case-control study, 20 individuals with a definite histopathology diagnosis of OSCC were selected as the case group and 20 healthy subjects were selected as the control group. The two groups were matched according to age, gender, cigarette smoking and alcohol consumption, medication consumption, periodontal disease (average CAL in first molars) and absence of systemic diseases. 5 ml of unstimulated whole saliva sample was collected with spitting method from each subject and the concentrations of salivary IL-8 were compared between the two groups. Linear regression and t-test were used for statistical analysis. Results: The concentration of IL-8 equaled 741.82±122.81 pg/ml in the case group and 341.25±83.52 pg/ml in the control group and t-test showed that the concentration of IL-8 in patients with OSCC is higher than that in the control subjects and this difference is significant. (p=0.049) According to regression equation, IL-8 has a significant correlation with tumor size index (T). (p=0.011) Conclusion: The results of this study showed that the concentrations of salivary IL-8 were significantly different between the patients with OSCC and healthy subjects (p=0.049) and the concentration of IL-8 has a significant correlation with tumor size (T).

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Salivary level of interleukin-8 in oral precancer and oral squamous cell carcinoma

Cited by 79 publications

References 44 publications

Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

Chemokines in tumor proximal fluids

Comparison of the concentration of salivary IL8 in patients with oral squamous cell carcinoma and healthy subjects

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