Background:Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The present study was undertaken to quantify the mast cells in health and disease, whether they correlate degree of inflammation and clinical features of periodontium.Materials and Methods:Ten cases of localized chronic periodontitis (CP), 10 cases of dental plaque-induced gingivitis (DPIG) and 10 cases of clinically healthy gingival tissues were selected. Samples were obtained from patients undergoing for periodontal surgery in CP and DPIG. In health group third molar impacted and covered with operculum without any inflammation were selected. Sample fixed in 10% buffered formalin and stained with Toludine blue stain and observed under binocular microscope.Conclusion:In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines.
Aim:The study was outlined to determine and assess the C-reactive protein (CRP) level in chronic periodontitis patients and to assess the CRP values after using Dental Air Force home dental cleaning system. Materials and methods:A total of 100 adult chronic periodontitis subjects were recruited voluntarily for this study. Clinical assessment of plaque index, gingival index, probing depth, clinical attachment level and C-reactive protein (CRP) levels were made prior to phase-1 therapy and at 7th and 15th day posttherapy. Effects of treatment were assessed by paired tests and analysis of variance by treatment group with baseline covariates. Comparative assessments were done among all the patients that were divided into four groups. Results:The results of this study showed that there was 35% decrease in CRP level in periodontitis patients that used Dental Air Force home dental cleaning system without undergoing phase 1 (complete scaling and root planing) therapy. There was 100% decrease in CRP in group D (phase 1 therapy followed by use of Dental Air Force home dental cleaning system) as compare to group C (phase 1 therapy followed by use of toothbrush) where there were 89.61% decrease in CRP level from baseline to 15th day of recordings.
Various acute phase reactants are produced in response to inflammatory stimuli, one of them is C-reactive protein which is. Serum levels of C-Reactive protein are useful to monitor and diagnose inflammatory process associated with disease as it being one of the valuable biomarkers in various clinical conditions, increase in level of C-Reactive protein is found in subjects with periodontal disease, which in turn can act as useful biomarker to diagnose cardiovascular disease, adverse pregnancy outcome as they being associated with periodontal disease. This manuscript is brief overview of C-Reactive protein and its relation with periodontal disease and systemic health.
Aim This pilot study was aimed to evaluate the efficacy of sea salt-based oral rinse as adjunct with conventional oral hygiene measures in gingivitis patients in terms of clinical parameters. Materials and methods A total 30 gingivitis patient between the ages of 18 and 55 years were enrolled in the study and divided under two categories. Clinical parameters were recorded prior to phase one therapy; and subjects were put on different oral hygiene regime with and without sea salt-based mouth rinse. At baseline and 3rd month subjects were evaluated. Results The results of this study showed that there was significant decrease in clinical parameters from baseline to 3 months in both the groups (p < 0.01). The subjects under groups using sea salt-based mouthwash showed a highly significant reduction to all the parameters as compared to subjects under groups using a conventional toothbrushing only. Conclusion Thus, we can conclude that long-term regular use of sea salt-based product seems to be more beneficial. How to cite this article Mani A, Mani S, Anarthe R. A Clinical Pilot Study to Evaluate the Efficacy of Sea Salt Based Oral Rinse in Gingivitis Patients. Int J Experiment Dent Sci 2015;4(2):116-118.
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