Correlation of mast cells in periodontal diseases

Lagdive, Sushma; Lagdive, Sanjay B; Mani, A.; Anarthe, Raju; Pendyala, Gowri; Babita, Pawar; Marawar, P. P.

doi:10.4103/0972-124x.107500

Cited by 27 publications

(23 citation statements)

References 11 publications

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“…Mast cell reaction has been investigated in periodontal disease by many authors and conflicting results have been reported (Lagdive et al, 2013;Steinsvoll et al, 2004;Batista et al, 2005;Gemmell et al, 2004). Some authors found a decreased mast cell density, while others noticed a significant increase.…”

Section: Discussionmentioning

confidence: 99%

Mast cells as key players in periodontal disease

Popovici

Ceauşu

Cîmpean

et al. 2014

ARCH BIOL SCI BELGRA

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Mast cell (MC) active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0 to 3, and the MCs were counted using the hotspot method. Intraepithelial MCs were scored from 0 to 2. We found a significant increase of mast cell density in cases with mild and moderate inflammatory changes, and a slight decrease in patients with severe periodontal disease. We noticed a higher degranulation rate in patients with periodontal disease compared to those with healthy mucosa. Intraepithelial MCs were found in cases with periodontal disease only and were correlated with the severity of the inflammatory lesion. MCs are important cellular components of the early stages of periodontal disease. Contrary to other studies, we found that MC density and activation increases with moderate inflammation but decreases in severe inflammatory lesions. Our data suggest that MCs are key players in the progression of inflammatory lesions of the gingiva. In advanced-stage periodontal disease, intraepithelial MCs apparently play an important role, although their biological significance remains to be fully understood.

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Section: Discussionmentioning

confidence: 99%

Mast cells as key players in periodontal disease

Popovici

Ceauşu

Cîmpean

et al. 2014

ARCH BIOL SCI BELGRA

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“…A significant increase in mast cell density has been found in gingival inflammation, but no explanation regarding their implication in the maintenance and progression of the inflammatory process has been revealed [52]. Moreover, there are no data on the relationship between MCs and the density of the inflammatory infiltrate.…”

Section: Mast Cell Gameplay In Oral Inflammationmentioning

confidence: 99%

Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity

Gaje

Ceauşu

Jitariu

et al. 2016

BioMed Research International

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Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity. These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on. MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma. By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients.

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“…MCs are normal residents of the lamina propria of human oral mucosa and gingiva 8 . They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with periodontal disease 9 . In their cytoplasm, they contain about 80 to 300 granules which exhibit metachromasy and toluidine blue staining 10 .…”

Section: Introductionmentioning

confidence: 99%

Quantification of mast cells in different stages of periodontal disease

Marjanović

Andjelkovic²,

Brkić

et al. 2016

VOJNOSANIT PREGL

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Increase in the number of mast cells in the infected gingiva can be correlated with an increased influx of inflammatory cells from blood circulation into the gingival stroma, as well as with the collagen lysis, since these cells produce substances with collagenolytic potential. Based on the distribution of mast cells, it could be concluded that in the evolution of periodontal disease there are significant dynamic alterations in migration and localization of these cells.

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Correlation of mast cells in periodontal diseases

Cited by 27 publications

References 11 publications

Mast cells as key players in periodontal disease

Mast cells as key players in periodontal disease

Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity

Quantification of mast cells in different stages of periodontal disease

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