Background:Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The present study was undertaken to quantify the mast cells in health and disease, whether they correlate degree of inflammation and clinical features of periodontium.Materials and Methods:Ten cases of localized chronic periodontitis (CP), 10 cases of dental plaque-induced gingivitis (DPIG) and 10 cases of clinically healthy gingival tissues were selected. Samples were obtained from patients undergoing for periodontal surgery in CP and DPIG. In health group third molar impacted and covered with operculum without any inflammation were selected. Sample fixed in 10% buffered formalin and stained with Toludine blue stain and observed under binocular microscope.Conclusion:In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines.
These data suggest that level of IL-8 is associated with periodontal status. The level of IL-8 in GCF is valuable in detecting the inflammation of periodontal tissue.
Dental implantology is the state of the art technique to replace missing teeth. Implant stability of implant jeopardizes its longevity and success of treatment. This study evaluates the implant stability of implant before and after 4 months of the implant placement, but before prosthetically loading it. Ten two-stage implants of Life care and Nobel Biocare dental implants were placed in 20 patients. Digital OPG was taken on the day of implant placement. After 4 months, at the time of second stage surgery, the implant stability was evaluated by the Periotest instrument. Four months after the implant placement, Periotest evaluation showed a mean of 1.9, which indicated that implants were well osseointegrated and stable. Even before prosthetically loading the two-stage implant, crestal bone loss of 0.6-0.9 mm occurred around the implant. The smooth polished collar design of the implant may have contributed to crestal bone loss.
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