Mast cells as key players in periodontal disease

Popovici, Ramona Amina; Ceauşu, Raluca Amalia; Cîmpean, Anca Maria; Talpoș, Şerban; Raica, Marius; Gaje, Pușa Nela

doi:10.2298/abs1402801p

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…In our material, MCs were found neither in epithelium of healthy gingiva, nor in gingivitis, but in some samples of moderate to advanced periodontal disease they were found in oral epithelium. Similar results were recently published by Popovici et al 16 . These authors found that the number of intraepithelial MCs increases with the severity of inflammation and intraepithelial MCs could be important in the evaluation of the severity of periodontal disease.…”

Section: Discussionsupporting

confidence: 93%

Quantification of mast cells in different stages of periodontal disease

Marjanović

Andjelkovic²,

Brkić

et al. 2016

VOJNOSANIT PREGL

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Increase in the number of mast cells in the infected gingiva can be correlated with an increased influx of inflammatory cells from blood circulation into the gingival stroma, as well as with the collagen lysis, since these cells produce substances with collagenolytic potential. Based on the distribution of mast cells, it could be concluded that in the evolution of periodontal disease there are significant dynamic alterations in migration and localization of these cells.

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Section: Discussionsupporting

confidence: 93%

Quantification of mast cells in different stages of periodontal disease

Marjanović

Andjelkovic²,

Brkić

et al. 2016

VOJNOSANIT PREGL

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“…Moreover, an increased amount of IL 1beta, IL 4, IL-6, TNF-alpha and IFN gamma was observed. Cytokine production is involved in the recruitment of Langerhans cells and clonal expansion of cytotoxic T cells [10,13].…”

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confidence: 99%

Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus

Georgescu¹,

Ene²,

Nicolae³

et al. 2017

Rev. Chim.

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Reflectometric technique for analyzing urine strips represents a simple, fast and inexpensive method, with no risk and discomfort for the patient. In the present paper, the authors conducted a retrospective study on the possible association between lichen planus (LP) and a number of pathological conditions that produce changes of urine metabolites. A retrospective study was made on 77 patients with LP (49 cases of cutaneous LP - CLP, 28 cases of oral LP - OLP) who were diagnosed and treated in the dermatology department of Victor Babes Hospital for Infectious and Tropical Diseases. The quantification of certain urine metabolites in the spontaneous urine through reflectometric technique may reveal liver diseases (urobilinogen, bilirubin), kidney diseases (erythrocytes, proteins, albumin, creatinine, albumin/creatinine ratio, urine specific gravity, pH), metabolic disorders (glucose, ketones, pH, ascorbic acid) and urinary diseases (leucocyturia, nitrites, proteins, erythrocytes). The evaluation of the patients included clinical examination and laboratory and imaging tests. Among the investigated patients with LP we found: 16 cases of hepatic dysfunction (20.8%), 7 cases of renal dysfunction (9.1%), 11 cases of metabolic disorders (14.3%) and 14 cases of urinary tract infections (18.2%). No differences were found between patients with cutaneous and oral LP. The linear regression analysis revealed: positive association between concentrations of urobilinogen and bilirubin (r = 0.174, p = 0.044), negative association between albumin and creatinine (r = -0.316, p = 0.007), positive association between glucose and ketones (r = 0.266, p = 0.098) and positive association between leucocyturia and urine nitrite levels (r = 0.202, p = 0.050). Based on clinical and laboratory data, 85.7% of results obtained from urine biochemistry were confirmed. This analysis did not find any difference between patients with cutaneous and oral LP. By determining a full panel of urine metabolites through reflectometric analysis we were able to identify the main pathological changes in patients with LP.

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“…Mast cells in periodontal disease were studied by a number of researchers and often different results were obtained because they used variable mast cell counting methods and the insufficient number of samples. [ 5 9 18 ]…”

Section: Discussionmentioning

confidence: 99%