Role of annular pentameric molecule: C-Reactive protein in periodontal disease and its association with systemic health

Kale, Preeti; Mani, A.; Anarthe, Raju; Mustilwar, Rachita G

doi:10.3233/jcb-210049

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…They are growth factors and differentiating factors, bone morphogenic proteins, extracellular matrix proteins, mediators of bone metabolism, and arachidonic acid metabolites. [2,3] Growth factors are mitogenic cytokines secreted by certain cells that can be shown to stimulate cell division of their own or in other specific cells. They mediate cellular proliferation, cell locomotion, contractility and differentiation, which are important for growth and wound healing.…”

Section: Biological Mediatorsmentioning

confidence: 99%

“…[1] In fact, the identity of a particular tissue is defined by the biochemical nature of the extra-cellular matrix it contains as well as the phenotype of the cells within it positioned in a particular spatial relationship to one another and to neighbouring tissue types. [2] Recent clinical investigations with focus on regeneration of the periodontium have attempted to define factors involved in the formation of a new connective tissue attachment to periodontally diseased or denuded root surfaces. [3]…”

Section: Introductionmentioning

confidence: 99%

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Growth Factors: Key Biological Mediators Involved in Periodontal Regeneration

Kale¹,

Mani²,

Agrawal³

2022

Int J Res Rev

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Section: Biological Mediatorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Growth Factors: Key Biological Mediators Involved in Periodontal Regeneration

Kale¹,

Mani²,

Agrawal³

2022

Int J Res Rev

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“…immune response to periodontitis. 3 The bacteria associated with periodontitis are recognized by TLRs on immune cells, which triggers an inflammatory response. This response is intended to eliminate the bacteria and repair the damaged tissue, but if it becomes chronic, it can lead to further tissue destruction and bone loss.…”

Section: Introductionmentioning

confidence: 99%

Sensing and signaling in periodontal inflammation via toll like receptors: A review

Kale,

Vasanth,

Shah

et al. 2023

IJPI

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Periodontal disease is a chronic inflammatory condition that affects the supporting structures of teeth, including the gingiva, periodontal ligament, and alveolar bone. Toll-like receptors (TLRs) play a crucial role in the recognition of pathogen-associated molecular patterns (PAMPs) from bacteria that cause periodontal disease. TLR activation triggers an inflammatory response that aims to eliminate the bacteria and repair damaged tissue. However, if the inflammation persists, it can lead to further tissue destruction and bone loss. This review discusses the mechanisms of TLRs in periodontal disease progression, including the recognition of bacteria, activation of immune cells, tissue destruction, and inhibition of immune response. Strategies for down-regulating TLRs, such as small-molecule inhibitors, antibodies, natural products, micro RNA, and nutritional interventions, are also discussed. Targeting TLRs is a promising therapeutic approach for reducing chronic inflammation associated with periodontal disease. Further research is needed to develop safe and effective strategies for down-regulating TLRs in humans.

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Scaffolds in tissue engineering

Sachdeva

Mani

Vora

et al. 2022

JCB

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Tissue engineering comprises of an array of specialities which combines biology, chemical sciences, engineering and material sciences for the regeneration of diseased tissues. In the novel world of tissue engineering, the fabrication and role of scaffolds is vital. Scaffolds have been engineered in such a fashion that it causes the desirable cellular interactions for the formation of new tissues for medical purposes. Ideal characteristics of scaffold include; three –dimensional and highly porous, should be biocompatible and bioresorbable, should have suitable surface chemistry for cell attachment, proliferation, and differentiation and must have mechanical properties to match those of the tissues at the site of implantation. A high porosity and an adequate pore size are necessary to facilitate cell seeding and diffusion throughout the whole structure of both cells and nutrients. The ever- evolving world of medical science will now in the near future be able to regenerate the lost tissues with the advancements of tissue engineering.

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Role of annular pentameric molecule: C-Reactive protein in periodontal disease and its association with systemic health

Cited by 4 publications

References 15 publications

Growth Factors: Key Biological Mediators Involved in Periodontal Regeneration

Growth Factors: Key Biological Mediators Involved in Periodontal Regeneration

Sensing and signaling in periodontal inflammation via toll like receptors: A review

Scaffolds in tissue engineering

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