Objectives: The objective of the study was to develop controlled release matrix tablet of zidovudine and to understand the release kinetics of drug by applying several mathematical model dependant and independent approaches. Various equations and models are developed for evaluating the drug release. Comparison of original and predicted release profile was most common way for selection of optimum formulation. Methods: In this study drug release profiles are characterized by using several parameters like percentage of drug released at 1 h and 12 h (R 1h , R 12h ), dissolution efficiency at 2 h and 12 h (DE 2h , DE 12h ) and pair wise procedures such as similarity factor (f 1 ), difference factor (f 2 ) and rescigno indices (ξ 1 , ξ 2 ) for getting the optimum formulation. Six batches (C1 to C6) of different concentration of carbopol embedded controlled release matrix tablets of Zidovudine were evaluated.
In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.
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