Goodness of fit Model Dependent Approaches of Controlled Release Matrix Tablets of Zidovudine.

Abstract

Objectives: The objective of the study was to develop controlled release matrix tablet of zidovudine and to understand the release kinetics of drug by applying several mathematical model dependant and independent approaches. Various equations and models are developed for evaluating the drug release. Comparison of original and predicted release profile was most common way for selection of optimum formulation. Methods: In this study drug release profiles are characterized by using several parameters like percentage of drug released at 1 h and 12 h (R 1h , R 12h ), dissolution efficiency at 2 h and 12 h (DE 2h , DE 12h ) and pair wise procedures such as similarity factor (f 1 ), difference factor (f 2 ) and rescigno indices (ξ 1 , ξ 2 ) for getting the optimum formulation. Six batches (C1 to C6) of different concentration of carbopol embedded controlled release matrix tablets of Zidovudine were evaluated.

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions

“…The following equations describe the model-dependent mathematical kinetics [ 24 ]. The best-fitting equation uses the coefficient of determination ( R 2 ), adjusted coefficient of determination ( R adjusted 2 ), and Akaike information criterion (AIC) [ 26 ]. According to the previously defined criteria for selecting the best kinetic model, the best and most accurate models should be selected using appropriate metrics such as R 2 , R adjusted 2 , and AIC.…”

Assessment of Drug Release Kinetics and Quality of Naproxen Generic Tablets in Bangladesh

“…The Korsmeyer-Peppas model provides the highest R 2 and adjusted R 2 and the lowest AIC values. This model is generally used to analyze the release of pharmaceutical exponents, which is indicated for polymeric dosage forms when the release mechanism is not well known or when more than one type of release phenomena is involved (27).…”

Development of Floating Tablets of Metformin HCl by Thermoplastic Granulation. Part II:In VitroEvaluation of the Combined Effect of Acacia Gum/HPMC on Biopharmaceutical Performances

“…The mechanism of release was determined by fitting the in vitro release data to the various kinetic equations: Zero order, First order, Higuchi and model Korsmeyer-Peppas. [10][11][12][13][14][15][16][17][18][19][20][21] For the high-performance formulations, the coefficient of determination (R 2 ) and Akaike information criteria (AIC) 22,23 of the dissolution profile corresponding to each model were determined. The highest R 2 and the lowest AIC of a model nominated it as the best fitting model.…”