Self Emulsifying Drug Delivery System: A Recent Approach

Bindhani, Sabitri; Mohapatra, Snehamayee; Kar, Rajat Kumar

doi:10.14233/ajchem.2019.21569

Cited by 5 publications

(3 citation statements)

References 85 publications

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“…Increased surface area of the SLMs through globules formulation r the absorption of the drug molecule, led to enhanced intestinal permeability thus resulting in improved bioavailability and subsequent reduction in parasitemia. These findings in improved bioavailability collaborated the work of Bindhani et al 40 Literatures have shown that the bioavailability of artemetherlumefantrine increases with the administration of milk or fatty meals. 8 The formulation of artemether-lumefantrine in fatty microparticles could have improved its bioavailability as the solid lipid microparticles could have protected the entrapped artemetherlumefantrine from degradation.…”

Section: In Vivo Studiessupporting

confidence: 76%

Formulation, In vitro and In vivo Evaluation of Sustained released Artemether-Lumefantrine-Loaded microstructured solid Lipid Microparticles (SLMs)

2021

TJNPR

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Section: In Vivo Studiessupporting

confidence: 76%

Formulation, In vitro and In vivo Evaluation of Sustained released Artemether-Lumefantrine-Loaded microstructured solid Lipid Microparticles (SLMs)

2021

TJNPR

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“…Medicines: A large number of herbal drugs and traditional medicines are being exploited and used for the development of SMEDDS because most of them have volatile and fixed oils 34,35 .…”

Section: Smedds For Herbal Drugs and Traditionalmentioning

confidence: 99%

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2020

IJPSR

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Oral route has always been the preferred route of drug administration in many diseases. This route is limited to those drugs molecules that are permeable across the gastric mucosa and are sparingly soluble. Solubility is an important parameter to achieve the desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new active lipophilic compounds that are poorly water-soluble. It is a challenge for a scientist to convert those molecules into an orally administered formulation with sufficient bioavailability. Improving oral bioavailability of poorly watersoluble drugs using self micro emulsifying drug delivery systems (SMEDDS) appears most promising. Currently, various technologies are available to deal with insoluble drugs such as micronization, solid dispersions, complex formation, etc. Among the several approaches, SMEDDS has emerged as a distinctive approach used to improve the bioavailability of hydrophobic drugs. SMEDDS is isotropic mixture of drug, surfactants, cosurfactants, and oil which have unique ability to form fine o/w microemulsion on slight shaking followed by dilution with gastrointestinal fluid. In-vitro features such as concentration of surfactants, ratio of oil to surfactant, zeta potential, and size of droplet play a crucial role in drug absorption orally. The present article compiled comprehensively which gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules. It also provides a discussion on recent developments in SMEDDS and solid SMEDDS, their characterization and applications. INTRODUCTION: As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly watersoluble. About 40% of new drugs exhibit poor water solubility, resulting in lack of dose proportionality, high inter-and intra-subject variability, and low oral bioavailability.

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“…Oral drug delivery is the most convenient and preferable route for administration of drugs because of low cost and easy administration (Bindhani et al, 2019). The oral route is the preferred route for chronic drug therapy.…”

Section: Introductionmentioning

confidence: 99%

Preparation of self micro emulsifying drug delivery system(smedds) of poorly soluble drug eprosartan mesylate and its in vitro evaluation

Bindhani¹,

Mohapatra²,

Kar³

et al. 2019

ijrps

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Eprosartan Mesylate (EM), an angiotensin II receptor blocker used in the treatment of high blood pressure. But poor solubility and bioavailability (13%) of eprosartan mesylate is a major challenging factor for improving its drug release rate. The main objective of the present work to develop and characterize self micro emulsifying drug delivery system of eprosartan mesylate by using compatible oil, surfactant and co-surfactant. For the selection of oil, surfactant and cosurfactant, solubility screening studies has been carried out. The nine formulations are prepared using peppermint oil, tween 80 and PEG 400. A pseudo ternary phase diagram was prepared to determine the self emulsion region. Four optimized formulations were prepared at 1:1 ratio(a mixture of surfactant and cosurfactant). These four formulations were evaluated for self-emulsification time, droplet size measurement, drug content analysis robustness to dilution test, viscosity analysis, f.t.i.r. The study and in-vitro diffusion studies. The ratio of scosmix (a mixture of surfactant and cosurfactant) of optimized formulation (pf5) was varied to pfa1 (2:1), pf2 (3:1), pfa3 (1:2) and compared with pure drug. The formulation having pfa1 (2:1) shown drug release of 93.13 % in 330 minutes where as pure drug showed a drug release of 54.51% in 330 minutes. So the prepared SMEDDS formulations were efficient and better than the pure drug, and it followed Korsmeyer pappes due to highest r2 value followed by Hixon crowel. It was concluded that incorporation of eprosartan mesylate in selfmicroemulsifying system is a great potential for improving the solubility and dissolution rate of eprosartan mesylate.

show abstract

Self Emulsifying Drug Delivery System: A Recent Approach

Cited by 5 publications

References 85 publications

Formulation, In vitro and In vivo Evaluation of Sustained released Artemether-Lumefantrine-Loaded microstructured solid Lipid Microparticles (SLMs)

Formulation, In vitro and In vivo Evaluation of Sustained released Artemether-Lumefantrine-Loaded microstructured solid Lipid Microparticles (SLMs)

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Preparation of self micro emulsifying drug delivery system(smedds) of poorly soluble drug eprosartan mesylate and its in vitro evaluation

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