The current study is aimed at developing Plantago ovata F. husk mucilage (PHM)‐blended Zn2+‐crosslinked low methoxyl (LM) pectinate (PHM‐Zn2+‐LM‐pectinate) controlled‐release matrices containing aceclofenac (ACF) for the management of rheumatoid arthritis (RA) in patients with an outright zinc deficiency. The ACF‐encapsulated hydrogel matrices are accomplished by ionic gelation using ZnSO4 as a crosslinker. The matrix diameter ranges from 1.39 ± 0.14 to 1.62 ± 0.16 mm. These formulations demonstrate excellent drug encapsulation efficiency (DEE, 63.80 ± 1.73–90.56 ± 2.72%) and controlled drug‐release behavior over a prolonged period of time (Q10 h, 51.42 ± 3.10 to 92.60 ± 2.38%). The drug‐elution patterns of different matrices are best‐fitted by a zero‐order kinetic model with a case‐II‐transport‐driven mechanism. The matrices also depict pH‐dependent swelling and degradation properties. In addition, the composites are characterized by scanning electron microscopy (SEM), Fourier transform IR (FTIR), and powder X‐ray diffraction (P‐XRD) analyses. Thus, the newly developed PHM‐Zn+2‐LM‐pectinate matrices could be appropriate for controlled ACF delivery along with Zn supplementation in the effective treatment of RA.
The objective of present research deals with the utility of extracted dillenia fruit gum (DG) as pharmaceutical excipient in the formulation of buccal patches containing atenolol (for the use in the treatment of hypertension). The atenololreleasing buccal patches having a mucoadhesive polymeric layer of extracted DG-hydroxypropyl methylcellulose (HPMC K4M) and a drug-free backing layer of ethyl cellulose (1%) were prepared through the solvent-casting process. Various physicochemical parameters such as drug content, average weight, thickness, folding endurance and moisture content of all these buccal patches were found satisfactory. Ex vivo buccoadhesion was also found satisfactory. Ex vivo drug permeation across the excised porcine buccal mucosal membrane demonstrated the atenolol permeation over 12 h, which obeyed the first-order model (R 2 = 0.9858-0.9967) with non-Fickian (anomalous) diffusion mechanism (n = 0.72-0.75). These buccal patches were also characterized by SEM and FTIR spectroscopy. These atenolol-releasing buccal patches can be used in the treatment of hypertension and angina pectoris bypassing the extensive hepatic first-pass metabolism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.