Antioxidants are compounds that have an important role in health because they can be used as anti-toxic molecules in the body which are the cause of various diseases. One of the plants that have antioxidant content is kratom (MitragynaspeciosaKorth). The purpose of this study was to determine the antioxidant activity of kratom leaf ethanol extract by using the DPPH trapping method. Exploration of kratom leaf samples was carried out by maceration using ethanol 96%, macerate was evaporated with a rotary evaporator, phytochemical screening of kratom leaf ethanol extract and antioxidant testing of DPPH as Free radical. Result of Simplisia Characterization of kratom leaves containing water, air soluble extract contents, ethanol-soluble extract levels, total ash content, and acid insoluble ash content sequentially as follows: 6.65; 18.01; 9.45; 7.14; and 1.06%. Phytochemical Screening results containing kratom leaf ethanol extract containing chemical composition: alkaloids, flavonoids, triterpenoids/steroids, saponins, and tannins. The results of antioxidant activity testing showed that ethanol extract had an IC50 value of 38.56 μg / ml. The results showed that the ethanol extract of kratom leaves had antioxidant activity in a very strong category.
ABSTRAKAntibiotik merupakan obat yang penting digunakan dalam pengobatan infeksi akibat bakteri. Tingginya penggunaan antibiotika yang tidak tepat pada masyarakat disebabkan kurangnya pengetahuan tentang antibiotika yang menyebabkan meningkatnya masalah resistensi antibiotika. Pengabdian masyarakat ini bertujuan untuk melihat bagaimana tingkat pengetahuan masyarakat di Desa Tembung tentang penggunaan antibiotika. Pengabdian masyarakat ini merupakan Pengabdian masyarakat deskripsi, dengan metode pendekatan crosssectional, menggunakan instrumen berupa kuesioner. Total 30 responden dalam Pengabdian masyarakat ini adalah penduduk Lingkungan III, Kelurahan Tembung, Kecamatan Medan Tembung, Kota Medan. Hasil yang diperoleh dari pengabdian ini adalah peningkatan pengetahuan masyarakat di Desa Tembung entang penggunaan antibiotik yang tepat. Adapun Kesimpulan kegiatan ini adalah edukasi dan Penyuluhan dapat meningkatkan pengetahuan masyarakat tentang penggunaan antibiotika. ABSTRACTAntibiotics are important drugs used in the treatment of infections caused by bacteria. The high number of inappropriate antibiotics in the community due to lack of knowledge about the use of antibiotics may lead to the increase of antibiotic resistance. Health education aimed to see how the level of public knowledge in Tembung Village on the use of antibiotics. Health education is description research in the community with cross-sectional methods, using instruments in the form of questionnaires. Total of 30 respondents in Health education were residents of in environment III, Tembung Village, Medan Tembung District, Medan City. The results obtained from this service were an increase in the knowledge of the people in Tembung village using appropriate antibiotics. The conclusion of this activity is education and health education can increase public knowledge about the use of antibiotics.
Skin disease was a disease that attacked the surface of the body, and was caused by various agents, one was bacteria. One of the plants that had antibacterial activity was jengkol leaf (Archidendron pauciflorum Benth.) I.C. Nielsen because it contained compounds that had antibacterial properties that had previously been studied by other researchers against Staphylococcus aureus and Escherichia coli bacteria. So that researcher was interested in researching on the antibacterial activity of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen against Staphylococcus epidermidis and Propionibacterium acnes. Fresh Jengkol leaves were processed into simplicia and extracted using 96% ethanol. Phytochemical screening was carried out on simplicia powder and extracts of jengkol leaves. Ethanol extract jengkol leaves was made in several concentrations, namely 20%, 25%, and 30%, positive control using Tetracycline HCl, and negative control using 1% DMSO. There were several tests carried out on jengkol leaves in addition to phytochemical screening, namely examination of simplicia characteristic including macroscopic examination, microscopic examination, examination of water content, examination of water-soluble extract levels, examination of ethanol-soluble extracts, examination of total ash content, and also an examination of acid-insoluble ash levels and antibacterial activity test of jengkol leaves. The results of phytochemical screening showed that the compound of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen contained a class of secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. And for the results of the antibacterial activity research also showed that jengkol leaves could be used as antibacterial because it has a strong inhibitory power at a concentration of 20% and the strongest at a concentration of 30% against Staphylococcus epidermidis, namely 15.06 mm and 17.83 mm, while in diameter of growth inhibition zone Propionibacterium acnes was 15.86 mm and 18.1 mm.
Penggunaan tumbuhan herba rumput bambu sebagai ramuan obat sangat berkaitan dengan kandungan kimia yang terdapat dalam tumbuhan tersebut terutama zat aktif biologisnya. Senyawa bioaktif yang terdapat dalam tumbuh-tumbuhan biasanya merupakan senyawa metabolit sekunder seperti steroid, flavonoid, alkaloid, saponin, terpenoid dan tannin, tanaman yang mengandung senyawa metabolit sekunder yaitu herba rumput bambu. Tujuan penelitian ini adalah untuk mengetahui senyawa kimia dan nilai flavonoid total ekstrak etanol herba rumput bambu.Tahapan penelitian ini meliputi pengolahan bahan tumbuhan, pembuatan ekstrak etanol, pemeriksaan karakterisasi simplisia, skrining fitokimia dan penetapan kadar flavonoid total ekstrak etanol herba rumput bambu dengan metode spektrofotometri visible. Hasil dari penelitian ini dapat disimpulkan bahwa pada ekstrak etanol herba rumput bambu terdapat kandungan golongan senyawa kimia seperti alkaloid, flavonoid, tanin, saponin dan steroid/triterpenoid dan hasil penentuan kadar flavonoid total pada ekstrak etanol herba rumput bambu sebesar 223.4188 ± 0.6749 mg QE/g.
Cancer is a disease characterized by uncontrolled cell division and the ability of these cells to invade other biological tissues, either by direct growth in adjacent tissues or by migration of cells to distant sites. The purpose of this study was to determine the class of secondary metabolites contained in the ethanol extract of cocoa leaves and their cytotoxicity by looking at the LC50 value using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of ethanol extract and the BSLT method by looking at the number of deaths of Artemia salina leach larvae (LC50). The results of phytochemical screening tests showed that the cocoa leaves contained flavonoids, alkaloids, tannins, saponins, steroids, and glycosides. The cytotoxicity test with probit analysis showed an LC50 value of 269,15 µg/mL, so it was concluded that the ethanol extract of cocoa leaves was toxic and had potential as an anticancer.
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