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Objective: To analyze the care practices of professionals from the Street Clinic team (SCt) about the care provided to users of alcohol and other drugs in Macapá, capital city of the state of Amapá. Method: Descriptive, qualitative study, carried out between April and June 2017. Ten SCt professionals participated. Five guiding questions were used for data collection, later analyzed through Bardin’s Thematic Content Analysis. Results: Facilitating care strategies involved harm reduction, teamwork, creating the link with users, team commitment and partnership with other members of the Psychosocial Care Network (PSCN). Of the factors that make care difficult, are the deficit of self-care, structural and human resources, and prejudice. Conclusion: Professionals are aware of the purpose and importance of SCt in strengthening PSCN. Conclusion: When conducting a practice based on public policies, care for the street population is facilitated.

Diabetes mellitus is associated with reactive oxygen and nitrogen species accumulation. Behavioral stress increases nitric oxide production, which may trigger a massive impact on vascular cells and accelerate cardiovascular complications under oxidative stress conditions such as Diabetes. For this study, type-1 Diabetes mellitus was induced in Wistar rats by intraperitoneal injection of streptozotocin. After 28 days, cumulative concentration-response curves for angiotensin II were obtained in endothelium-intact carotid rings from diabetic rats that underwent to acute restraint stress for 3h. The contractile response evoked by angiotensin II was increased in carotid arteries from diabetic rats. Acute restraint stress did not alter angiotensin II-induced contraction in carotid arteries from normoglycaemic rats. However acute stress combined with Diabetes increased angiotensin II-induced contraction in carotid rings. Western blot experiments and the inhibition of nitric oxide synthases in functional assays showed that neuronal, endothelial and inducible nitric oxide synthase isoforms contribute to the increased formation of peroxynitrite and contractile hyperreactivity to angiotensin II in carotid rings from stressed diabetic rats. In summary, these findings suggest that the increased superoxide anion generation in carotid arteries from diabetic rats associated to the increased local nitric oxide synthases expression and activity induced by acute restrain stress were responsible for exacerbating the local formation of peroxynitrite and the contraction induced by angiotensin II.

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