All tissues of the joint are affected in some way in osteoarthritis because the joint is an interactively functioning unit. Our goal was to investigate the combined responses of articular cartilage and subchondral bone to altered loading conditions to improve our understanding of the physiology of these two components and, ultimately, the pathophysiology of osteoarthritis. A group of 20 female beagle dogs were divided pairwise into runners (n = 10) and controls (n = 10). The running training on a treadmill started at the age of 15 weeks, and during the following 40 weeks the running distance was gradually increased to 40 km/day with a 15 degree uphill inclination. With this daily running distance the beagles ran another 15 weeks. The samples for histology were taken from 11 different locations of the knee joint. Subchondral bone and articular cartilage histomorphometry was carried out in three different regions of the specimens (central, middle, and peripheral regions) using an image-analyzing system and an eyepiece graticule. In all regions of the articular cartilage, both the uncalcified and calcified cartilage showed slightly increased thickness in the runner dogs. The change was more evident in the peripheral and the central areas. The thickness of the subchondral bone plate tended to be higher in runners, too. Bone histomorphometric parameters showed significant signs of increased remodeling. The most notable change was the enlargement of the bone formation surface. The most intense remodeling was usually observed either centrally or peripherally in the articular surface. The strongest increase in trabecular bone volume and thickness of the cartilage was recorded in the femoropatellar area.(ABSTRACT TRUNCATED AT 250 WORDS)
To assess prognosis and indications for allografting articular surfaces, osteological examination is of increasing importance. In this study 93 femoral heads of patients with primary osteoarthritis could be differentiated into three osteologic types using histomorphometry: (1) the osteosclerotic type (77% of cases), (2) the hyperostotic type, with excessive neogenesis of bone all over the femoral head and increased formation of osteophytes (10% of cases), and (3) the osteopenic type, with decreased bone mass and features of bone remodelling, a greater occurrence of subchondral cysts, and small osteophytes (8% of cases). Radiological and clinical features to distinguish these groups are given. The consequences for pathogenesis and clinical practice are discussed.
William Coley, between 1895 and 1936, treated hundreds of cancer patients using infusions of fever inducing bacerial extracts. Similar experiments were done by Klyuyeva and co-workers in the 1940ies in Russia using trypanosoma extracts. Many remissions and cures were reported. We have conjectured that pathogen associated molecular pattern substances (PAMP) are the molecular explanation for the beneficial treatments in both groups. We could show that a combination of PAMP can eradicate solid tumours in cancer mice if applied several times. Accordingly, we suggested to combine PAMP containing approved drugs to treat cancer patients using a protocol similar to the old fever induction regimen. In this retrospective phase-1 study we report on the fever induction capacity and safety of applications of bacterial extracts, combinations of bacterial extracts with approved drugs, and combinations of approved drugs in 131 mainly cancer patients. Adverse reactions were those which can be expected during a feverish infection and mild. Over 523 fever inductions, no severe adverse reaction was observed.
Was ist wichtig in der biologischen Krebstherapie?Ergebnisse einer 100-Fall-Datenanalyse funktionsdiagnostischer Verfahren zu Behandlungsbeginn (Teil 1) Vorbemerkungen ä Nahezu tä glich erreichen den interessierten Therapeuten neue Empfehlungen, Vitalstoffe, Naturheilmittel und Immuntherapeutika zur Beeinflussung des Krebsgeschehens. Es fällt immer schwerer, Wichtiges von Unwichtigem zu trennen. Dennoch ist man an einem Optimum an Therapieangebot fü r den Hilfe suchenden Krebspatienten interessiert und braucht ein Konzept der Differenzierung. Die nachfolgende Ergebnisdarstellung soll in diesem Sinne hilfreich sein, denn der Grundsatz "Hä ufiges kommt auch hä ufig vor" gilt auch in der biologischen Krebstherapie. Bei aller Notwendigkeit zur Individualisierung einer ganzheitlichen Behandlungsstrategie zeigen die Ergebnisse der biologischen Summationsdiagnostik klar Schwerpunkte auf, welche als Leitlinie einer wirkungsvollen und dazu kostengü nstigen Therapie geeignet sind. Ausgewertetes Patientengut und Datenmaterial Zur Auswertung kamen die Erstbehandlungsdaten von 100 Krebs-und Leukä miepatienten (Tab. 1), welche zwischen Januar und Oktober 2004 in der Klinik ProLeben stationä r behandelt wurden und eine vollstä ndige biologische Ergänzungsdiagnostik aufwiesen. Dabei wurden sä mtliche Tumorstadien und alle Arten von Vorbehandlungsstatus (Tab. 2) einbezogen. Die in Abbildung 1 farbig hervorgehobenen Test-und Analyseverfahren wurden auf-grund des hohen Maßes an Quantifizierbarkeit vordergrü ndig einer statistischen Auswertung unterworfen. Von den 100 Patienten hatten 4 im Vorfeld keinerlei schulmedizinische Standardbehandlung erfahren. Eine Operation war bei 63, Bestrahlung bei 35, Chemotherapie bei 53 und Hormontherapie bei 22 Patienten durchgefü hrt worden. Allein 15 Patienten hatten die Kombination aller Standardverfahren der Schulmedizin bekommen. ZusammenfassungDie Vielfalt an Behandlungsmö glichkeiten und Heilmittelempfehlungen im Rahmen der biologischen Krebstherapie machen es vielen Therapeuten schwer, eine effektive und kostengü nstige Behandlungsstrategie zu finden. Die vorliegende Analyse der Ergebnisdaten von 100 Krebs-und Leukä miepatienten zeigt die wichtigsten Ursachenfaktoren, Therapiehindernisse und biologischen Heilmittel auf, welche im Rahmen der Erst-(Eingangs-)analyse ermittelt wurden. Es werden die Ergebnisse der Elektroakupunktur nach Voll (EAV), Computer-Regulationsthermographie nach Prof. Rost (c-RTG) und PC-gestü tzten Kinesiologie mit dem SkaSys â -System dargestellt. Diese zur Auswertung gekommenen Messverfahren beleuchten alle biologischen Ebenen und ermö glichen hierdurch eine aussagekrä ftige Summationsdiagnostik als Basis einer individuellen und effektiven biologischen Immun-und Ganzheitstherapie. AbstractFor many therapeutists it is difficult, to find an effective and cost-advantageous treatment strategy because of the existing variety of treatments and recommendations for remedies within the framework of the biological cancer therapy. The present analysis of the result data of 100 ...
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