A 64-channel ASIC for Time-of-Flight Positron Emission Tomography (TOF PET) imaging has been designed and simulated. The circuit is optimized for the readout of signals produced by the scintillation of a L(Y)SO crystal optically coupled to a silicon photomultiplier (SiPM). Developed in the framework of the EndoTOFPET-US collaboration [1], the ASIC is integrated in the external PET plate and performs timing, digitization and data transmission for 511 keV and lower-energy events due to Compton scattering.Multi-event buffering capability allows event rates up to 100 kHz per channel. The channel cell includes a low input impedance low-noise current conveyor and two trans-impedance amplifier branches separately optimized for energy and time resolution. Two voltage mode discriminators generate respectively a fast trigger for accurate timing and a signal for time-over-threshold calculation, used for charge measurement. The digitization of these signals is done by two low-power TDCs, providing coarse and fine time stamps that are saved into a local register and later managed by a global controller, which builds-up the 40-bit event data and runs the interface with the data acquisition back-end.Running at 160 MHz the chip yields a 50 ps time binning and dissipates 7 mW per channel (simulated for 40 kHz event rate p/channel) for high capacitance photodetectors (9 mm 2 active area Silicon Photomultiplier with 320 pF terminal capacitance). The minimum SNR of 23.5 dB expected with this capacitance should allow triggering on the first photoelectron to achieve the envisaged timing performance for a TOF-PET system.

We present a readout and digitization ASIC featuring low-noise and low-power for time-of flight (TOF) applications using SiPMs. The circuit is designed in standard CMOS 110 nm technology, has 64 independent channels and is optimized for time-of-flight measurement in Positron Emission Tomography (TOF-PET). The input amplifier is a low impedance current conveyor based on a regulated common-gate topology. Each channel has quad-buffered analogue interpolation TDCs (time binning 20 ps) and charge integration ADCs with linear response at full scale (1500 pC). The signal amplitude can also be derived from the measurement of time-over-threshold (ToT). Simulation results show that for a single photo-electron signal with charge 200 (550) fC generated by a SiPM with 320 pF capacitance the circuit has 24 (30) dB SNR, 75 (39) ps r.m.s. resolution, and 4 (8) mW power consumption. The event rate is 600 kHz per channel, with up to 2 MHz dark counts rejection.

We present the experimental characterization of the TOFPET2, a readout and digitization ASIC for radiation detectors using Silicon Photomultipliers. The circuit is designed in CMOS 110 nm technology, has 64 independent channels and is optimized for time-of-flight measurement in PET or other applications. The chip has quad-buffered TDCs and charge integration QDCs in each channel. The Coincidence Time Resolution (CTR) of 511 keV photon pairs from a 22Na point source measured with 2 × 2 × 3 mm3 LSO:Ce crystals co-doped with 0.2% Ca is 118 and 119 ps FWHM when using respectively the SiPMs NUVHD 40um from Fondazione Bruno Kessler (FBK) and the S14160-3050HS MPPC from Hamamatsu Photonics (HPK). The energy resolution obtained for the 511keV photopeak is 10.5 and 12% FWHM when using respectively the SiPMs PM3325-WB from KETEK and the QFBR-S4N44P164S from Broadcom Inc.

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Ahstract-A 64-channel ASIC for TOF PET imaging is pre sented. The circuit provides time and energy measurements of events produced by a SiPM coupled to a L(Y)SO fast scintillator.This ASIC is developed in the framework of the EndoTOFPET US collaboration as an option for the readout of external 200x200 mm plate detector, which consists of 3x3x15 mm crystals and 3x3 mm (active area) SiPMs. Using the chip with non-segmented and/or higher light yield crystals is possible. The same applies for photodetectors with different gain, polarity, or even higher dark count rate. The targeted 200 ps timing resolution for the system and the need for a low power consumption have driven the choice of a closed-loop amplifier input stage and a 50 ps time binning TDC based on analogue interpolation. A power consumption between 5 to 10 mW per channel is expected to guarantee a SNR of at least 20 dB for the single photon, using a SiPM with 320 pF terminal capacitance.

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The Clear-PEM scanner for positron emission mammography under development is described. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes and readout by a fast low-noise electronic system. A dedicated digital trigger (TGR) and data acquisition (DAQ) system is used for on-line selection of coincidence events with high efficiency, large bandwidth and small dead-time. A specialized gantry allows to perform exams of the breast and of the axilla. In this paper we present results of the measurement of detector modules that integrate the system under construction as well as the imaging performance estimated from Monte Carlo simulated data. r