Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics

Abreu, M.C.; Aguiar, David; Albuquerque, E.; Almeida, F. G.; Almeida, Pedro de; Amaral, P.; Auffray, E.; Bento, Pedro; Bruyndonckx, Peter; Bugalho, R.; Carriço, B.; Cordeiro, Hugo; Ferreira, Miguel; Ferreira, Nuno C.; Gonçalves, Fernando M.; Lecoq, P.; Leong, C.; Lopes, Flávia Paiva Proença Lobo; Lousa, P.; Luyten, Joan; Martins, M. V.; Matela, Nuno; Mendes, P. Rato; Moura, R.; Nobre, J.; Oliveira, N.; Ortigao, Catarina; Peralta, L.; Rego, J.; Ribeiro, R.; Rodrigues, Pedro; Santos, Ana Isabel; Silva, J. C.; Silva, M. M.; Tavernier, S.; Teixeira, I.C.; Teixeira, J.P.; Trindade, A.; Trummer, J.; Varela, J.

doi:10.1016/j.nima.2006.10.034

Cited by 27 publications

(15 citation statements)

References 9 publications

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“…Edge-on, dual-ended readout and segmented detector designs have been proposed to reduce this effect in breast PET scanners (Wang et al , 2006; Abreu et al , 2007; Zhang et al , 2007; Kitamura et al , 2008). We are currently exploring a hybrid dual-ended readout detector design to solve this problem while maintaining a large detector packing fraction (Chaudhari et al , 2008c).…”

Section: Discussionmentioning

confidence: 99%

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

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A dedicated breast PET/CT system has been constructed at our institution, with the goal of having increased spatial resolution and sensitivity compared to whole-body systems. The purpose of this work is to describe the design and the performance characteristics of the PET component of this device. Average spatial resolution of a line source in warm background using maximum a posteriori (MAP) reconstruction was 2.5 mm, while average spatial resolution of a phantom containing point sources using filtered back projection (FBP) was 3.27 mm. A sensitivity profile was computed with a point source translated across the axial field of view (FOV) and the peak sensitivity of 1.64% was measured at the center of FOV. Average energy resolution determined on a per-crystal basis was 25%. Characteristic dead time for the front-end electronics and data acquisition (DAQ) was determined to be 145 ns and 3.6 µs, respectively. With no activity outside the FOV, a peak noise-equivalent count rate of 18.6 kcps was achieved at 318 µCi (11.766 MBq) in a cylindrical phantom of diameter 75 mm. After the effects of exposing PET detectors to x-ray flux were evaluated and ameliorated, the combined PET/CT scan was performed. The percentage standard deviations of uniformity along axial and transaixal directions were 3.7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial.

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Section: Discussionmentioning

confidence: 99%

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

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“…79 In addition to these commercial systems, there is a substantial amount of research activity focused on improving PEM and DbPET imaging technology. Several types of systems are currently under development by research groups around the world, including University of California-Davis, 80,81 Lawrence Berkeley National Laboratory, 82 Brookhaven National Laboratory, 83 Stanford University, 84 Duke University, 85 Thomas Jefferson National Accelerator Facility and West Virginia University, 86,87 MD Anderson, 88 University of Pisa, 89 the Crystal Clear Collaboration at CERN, [90][91][92] and Shimadzu Corporation. 93 The developers of these systems are beginning to collect initial patient data and rapidly moving toward clinical trials.…”

Section: Iiib Coincidence Detection Systemsmentioning

confidence: 99%

“…91 The Clear-PEM detector uses LYSO crystals that are coupled to multipixel avalanche photodiodes. By using 2 photodiodes per crystal in the Clear-PEM, a double readout of emitted light is performed, which in turn enables a depth of interaction (DOI) calculation to be done.…”

Section: Iiib Coincidence Detection Systemsmentioning

confidence: 99%

Nuclear imaging of the breast: Translating achievements in instrumentation into clinical use

Hruska

O’Connor

2013

Medical Physics

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Approaches to imaging the breast with nuclear medicine and/or molecular imaging methods have been under investigation since the late 1980s when a technique called scintimammography was first introduced. This review charts the progress of nuclear imaging of the breast over the last 20 years, covering the development of newer techniques such as breast specific gamma imaging, molecular breast imaging, and positron emission mammography. Key issues critical to the adoption of these technologies in the clinical environment are discussed, including the current status of clinical studies, the efforts at reducing the radiation dose from procedures associated with these technologies, and the relevant radiopharmaceuticals that are available or under development. The necessary steps required to move these technologies from bench to bedside are also discussed.

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“…Another solution is to determine the conversion point in the crystal by means of a light-sharing scheme with readout at both ends of the crystal. This solution has been chosen for 20 mm long LYSO crystals in the ClearPEM ® , a dedicated PET scanner for breast imaging [22] and provides a depth of interaction (DOI) resolution of better than 2 mm.…”

Section: B Improving Spatial Resolutionmentioning

confidence: 99%

Molecular Imaging Challenges With PET

Lecoq

2010

IEEE Trans. Nucl. Sci.

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Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics

Cited by 27 publications

References 9 publications

PET characteristics of a dedicated breast PET/CT scanner prototype

PET characteristics of a dedicated breast PET/CT scanner prototype

Nuclear imaging of the breast: Translating achievements in instrumentation into clinical use

Molecular Imaging Challenges With PET

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